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Home >> Antibodies >> DKK1 Antibody

DKK1 Antibody (F53121)

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  Catalog No Formulation Size Price (USD)  
Image F53121-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F53121-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of lysate from (1) A549, (2) HeLa, (3) HepG2, (4) Jurkat, (5) mouse NIH3T3 cell line using DKK1 antibody. Predicted molecular weight: 26-40 kDa depending on glycosylation level.
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Western blot analysis of lysate from (1) A549, (2) HeLa, (3) HepG2, (4) Jurkat, (5) mouse NIH3T3 cell line using DKK1 antibody. Predicted molecular weight: 26-40 kDa depending on glycosylation level.
Western blot testing of DKK1 antibody at 1:2000 dilution. Lane 1: A549; 2: Jurkat; 3: NIH3T3 lysate; Predicted molecular weight: 26-40 kDa depending on glycosylation level.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt O94907
Applications Western blot : 1:1000-1:4000
Limitations This DKK1 antibody is available for research use only.
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Description

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. [UniProt]

Application Notes

Titration of the DKK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This DKK1 antibody was produced from a rabbit immunized with a recombinant protein of human DKK1.

Storage

Aliquot the DKK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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