- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Desmoglein 3 Antibody Rabbit Monoclonal / DSG3 [clone DSG3/8251R] (V4572)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4572-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4572-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4572SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | DSG3/8251R |
| Purity | Protein A/G affinity |
| UniProt | P32926 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Desmoglein 3 antibody is available for research use only. |
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Desmoglein 3 Antibody Rabbit Monoclonal DSG3/8251R recognizes Desmoglein 3, a calcium-dependent desmosomal cadherin encoded by the DSG3 gene on chromosome 18q12.1. Desmoglein 3, also referred to as DSG3 in the literature, is a single-pass transmembrane glycoprotein localized to desmosomes at the plasma membrane of stratified epithelial cells, where it mediates strong intercellular adhesion and supports epithelial structural integrity. Desmoglein 3 antibody, also known as DSG3 antibody, is widely used in research focused on epithelial biology, mucosal differentiation, and autoimmune blistering diseases.
Desmoglein 3 is a member of the cadherin superfamily and functions as a core component of desmosomal junctions. Its extracellular cadherin repeats mediate calcium-dependent homophilic adhesion between adjacent epithelial cells, while its cytoplasmic domain associates with desmosomal plaque proteins including Plakoglobin and Desmoplakin. Through these interactions, Desmoglein 3 anchors keratin intermediate filaments to the plasma membrane, reinforcing mechanical stability in tissues exposed to friction and shear stress, particularly mucosal epithelia and basal epidermal layers.
Expression of DSG3 is predominantly observed in the basal and suprabasal layers of stratified squamous epithelia, including oral mucosa, esophagus, cervix, and skin. In contrast to Desmoglein 1, which is enriched in superficial epidermal layers, Desmoglein 3 is more abundant in deeper epithelial layers and plays a critical role in maintaining mucocutaneous adhesion. Autoantibodies directed against Desmoglein 3 are strongly associated with pemphigus vulgaris, where disruption of desmosomal adhesion leads to intraepidermal blister formation. Altered DSG3 expression has also been reported in squamous cell carcinomas and other epithelial malignancies.
Structurally, Desmoglein 3 contains multiple extracellular cadherin domains, a transmembrane region, and an intracellular tail that anchors to the desmosomal plaque complex. Beyond structural adhesion, DSG3 participates in signaling pathways that influence keratinocyte proliferation, differentiation, and epithelial homeostasis. Dysregulated expression may contribute to altered epithelial architecture and tumor progression in stratified epithelia. Through its essential role in desmosomal cohesion, Desmoglein 3 remains central to research in epithelial adhesion biology and mucocutaneous disease mechanisms.
Optimal dilution of the Desmoglein 3 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the Desmoglein 3 antibody rabbit monoclonal.
Aliquot the Desmoglein 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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