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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Desmoglein 3 Antibody / DSG3 [clone 5G11] (V3246)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3246-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3246-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3246SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | 5G11 |
| Purity | Protein G affinity chromatography |
| UniProt | P32926 |
| Localization | Cell surface |
| Applications | Flow Cytometry : 1-2ug/10^6 cells Immunofluorescence : 1-2ug/ml Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Desmoglein 3 antibody is available for research use only. |
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Desmoglein 3 Antibody Clone 5G11 recognizes Desmoglein 3, a calcium-dependent desmosomal cadherin encoded by the DSG3 gene on chromosome 18q12.1. Desmoglein 3, commonly referred to as DSG3 in the literature, is a single-pass transmembrane glycoprotein localized to desmosomes at the plasma membrane of stratified epithelial cells, where it mediates strong intercellular adhesion. DSG3 antibody, also known as Desmoglein 3 antibody, plays a central role in studies of epithelial cohesion, mucocutaneous integrity, and squamous differentiation. Clone 5G11 has been widely referenced in peer-reviewed research, contributing to its recognition as a well-established tool for investigating DSG3 biology.
Desmoglein 3 is a member of the cadherin superfamily and functions as a structural component of desmosomal junctions. Its extracellular cadherin repeats mediate calcium-dependent homophilic binding between adjacent epithelial cells, while its intracellular domain associates with desmosomal plaque proteins including Plakoglobin and Desmoplakin. Through these interactions, Desmoglein 3 anchors keratin intermediate filaments to the plasma membrane, reinforcing tissue stability in stratified squamous epithelia exposed to mechanical stress such as skin, oral mucosa, and esophagus.
DSG3 expression is predominantly observed in the basal and suprabasal layers of stratified squamous epithelium. In contrast to Desmoglein 1, which is enriched in superficial epidermal layers, Desmoglein 3 is concentrated in deeper epithelial layers and plays a critical role in maintaining mucocutaneous adhesion. Autoantibodies targeting Desmoglein 3 are strongly associated with pemphigus vulgaris, where disruption of desmosomal adhesion leads to intraepidermal blister formation. Altered DSG3 expression has also been reported in squamous cell carcinomas and other epithelial malignancies, making DSG3 antibody an important marker in oncologic and dermatologic research.
Structurally, Desmoglein 3 contains multiple extracellular cadherin domains, a transmembrane region, and an intracellular tail that integrates into the desmosomal plaque complex. Beyond its adhesive function, DSG3 participates in signaling pathways influencing keratinocyte proliferation and epithelial differentiation. Due to its extensive citation in scientific literature and consistent performance across epithelial research applications, Desmoglein 3 Antibody Clone 5G11 remains a widely recognized reagent for studying desmosomal biology and mucocutaneous disease mechanisms.
Optimal dilution of the Desmoglein 3 antibody clone 5G11 should be determined by the researcher.
A recombinant human protein corresponding to the extracellular portion of DSG3 was used as the immunogen for the Desmoglein 3 antibody clone 5G11.
Store the Desmoglein 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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