Desmoglein 2 Antibody (R30636)

Desmoglein 2 Antibody MCF7 IF. Immunofluorescence analysis of FFPE human MCF7 cells stained with Desmoglein 2 antibody (green) detecting DSG2. Membranous and cell-cell junction-associated fluorescence is observed outlining epithelial cell borders, consistent with localization of DSG2 to desmosomal adhesion complexes that maintain epithelial integrity. Signal is concentrated at intercellular contacts, while the cytoplasm shows lower intensity staining. DAPI (blue) highlights nuclei.

Desmoglein 2 Antibody Lung Cancer IHC. Immunohistochemistry analysis of FFPE human lung cancer tissue stained with Desmoglein 2 antibody detecting DSG2. Tumor epithelial cells show membranous and cytoplasmic staining, with accentuation along cell-cell borders consistent with localization of DSG2 in desmosomal adhesion complexes that support epithelial cohesion. Surrounding stromal and inflammatory cells show reduced staining. Hematoxylin counterstain highlights nuclei in blue. HIER: boil tissue sections in pH 8 EDTA buffer for 20 min and allow to cool before testing.

Desmoglein 2 Antibody Breast Cancer IHC. Immunohistochemistry analysis of FFPE human breast cancer tissue stained with Desmoglein 2 antibody detecting DSG2. Tumor epithelial cells demonstrate membranous and cytoplasmic staining with clear accentuation at cell-cell junctions, consistent with localization of DSG2 within desmosomal adhesion complexes that maintain epithelial structural integrity. Adjacent stromal elements show minimal staining. Hematoxylin counterstain highlights nuclei in blue. HIER: boil tissue sections in pH 8 EDTA buffer for 20 min and allow to cool before testing.

Desmoglein 2 Antibody Rat Intestine IHC. Immunohistochemistry analysis of FFPE rat intestine tissue stained with Desmoglein 2 antibody detecting DSG2. Epithelial cells lining intestinal glands and luminal surfaces show membranous and cytoplasmic staining with clear localization at cell-cell junctions, consistent with DSG2 presence in desmosomal adhesion complexes that maintain epithelial cohesion and structural integrity. Surrounding stromal tissue shows reduced staining. Hematoxylin counterstain highlights nuclei in blue. HIER: boil tissue sections in pH 8 EDTA buffer for 20 min and allow to cool before testing.

Desmoglein 2 Antibody Multi-Sample WB. Western blot analysis of human and rodent lysates using Desmoglein 2 antibody detecting DSG2. Lane 1: K562, Lane 2: HeLa, Lane 3: HepG2, Lane 4: A549, Lane 5: Caco-2, Lane 6: SW620, Lane 7: rat liver, Lane 8: mouse liver. A band is detected at approximately 130-160 kDa across multiple samples, consistent with the predicted molecular weight of Desmoglein 2, with variation reflecting glycosylation of this transmembrane desmosomal cadherin. The broad detection pattern across epithelial-derived cell lines and tissues supports DSG2 expression as a key component of desmosomal adhesion complexes involved in maintaining cell-cell junction integrity.

Desmoglein 2 Antibody 293T FACS. Flow cytometry analysis of human 293T cells stained with Desmoglein 2 antibody detecting DSG2. The antibody signal (blue) shows a clear rightward shift compared to cells alone (red) and isotype control (green), indicating positive surface-associated detection of DSG2. This pattern is consistent with Desmoglein 2 as a membrane-localized desmosomal cadherin involved in cell-cell adhesion.