- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Desmoglein 1 Antibody Goat Polyclonal (R36403)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R36403-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| UniProt | Q02413 |
| Gene ID | 1828 |
| Localization | Cell surface, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 4-6ug/ml ELISA (peptide) LOD : 1:32000 |
| Limitations | This Desmoglein 1 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Desmoglein 1 antibody recognizes Desmoglein 1, a calcium-dependent cadherin family adhesion protein encoded by the DSG1 gene on chromosome 18q12.1. Desmoglein 1 is a transmembrane glycoprotein localized to desmosomes within the plasma membrane of stratified epithelial cells, where it plays a critical role in cell-cell adhesion and epidermal integrity. Desmoglein 1 antibody, also referred to as DSG1 antibody in the literature, is widely used in research focused on epithelial differentiation, barrier formation, and autoimmune blistering diseases. This goat polyclonal antibody targets Desmoglein 1 for detection in research applications.
Desmoglein 1 is a member of the cadherin superfamily and functions as a core component of desmosomal junctions, interacting with other desmosomal cadherins such as Desmocollins and intracellular plaque proteins including Plakoglobin and Desmoplakin. Through these interactions, Desmoglein 1 anchors keratin intermediate filaments to the plasma membrane, reinforcing mechanical stability in tissues subjected to physical stress, particularly the epidermis. The extracellular cadherin repeats mediate calcium-dependent homophilic adhesion between adjacent cells, while the cytoplasmic domain links to the desmosomal plaque complex.
Expression of DSG1 is predominantly observed in the suprabasal layers of stratified squamous epithelia, including skin, oral mucosa, and esophagus. It is highly expressed in differentiated keratinocytes and contributes to epidermal barrier formation. Alterations in Desmoglein 1 expression or function are associated with several dermatologic conditions. Autoantibodies targeting Desmoglein 1 are implicated in pemphigus foliaceus, where disruption of desmosomal adhesion leads to superficial epidermal blistering. Mutations in DSG1 have also been linked to inherited skin disorders characterized by impaired barrier function and inflammatory phenotypes.
Structurally, Desmoglein 1 contains multiple extracellular cadherin domains, a single-pass transmembrane region, and an intracellular cadherin-like sequence that mediates interactions with desmosomal plaque proteins. Its regulated expression during keratinocyte differentiation supports stratification and tissue organization. Dysregulated desmosomal signaling may influence epidermal proliferation and inflammatory responses, highlighting the broader biological importance of Desmoglein 1 beyond adhesion alone.
This goat polyclonal Desmoglein 1 antibody is suitable for detecting DSG1 expression in research applications focused on epithelial biology, skin disease mechanisms, and desmosomal protein regulation. Explore our DSG1 Antibody - Desmosomal Adhesion and Epithelial Integrity Marker (clone MSVA-544M) page for a broader view of Desmoglein-1 expression across human tissue microarrays and epithelial stratification patterns.
Optimal dilution of the Desmoglein 1 antibody goat polyclonal should be determined by the researcher.
Amino acids YTTSDTLKPSVHVHD were used as the immunogen for this Desmoglein 1 antibody goat polyclonal.
Aliquot and store the Desmoglein 1 antibody at -20oC.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(19)