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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Desmin Antibody / DES (R31530)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R31530 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| Gene ID | 1674 |
| Localization | Cytoplasmic, membranous |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunohistochemistry (Frozen) : 2-5ug/ml Immunofluorescence : 5ug/ml |
| Limitations | This Desmin/Des antibody is available for research use only. |
|
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Desmin antibody targets Desmin, an intermediate filament protein encoded by the human DES gene and a major structural component of the cytoskeleton in muscle cells. Desmin is a muscle-specific type III intermediate filament protein primarily localized to the cytoplasm, where it forms a filamentous network surrounding Z-discs and linking the contractile apparatus to the sarcolemma, nucleus, and mitochondria. A Desmin antibody is widely used to identify skeletal, cardiac, and smooth muscle cells due to its highly specific expression pattern in myogenic tissues.
Desmin plays a critical role in maintaining structural integrity and mechanical stability during muscle contraction. It anchors myofibrils laterally and longitudinally, helping preserve sarcomere alignment and supporting force transmission across muscle fibers. In cardiac and skeletal muscle, Desmin interacts with other cytoskeletal and membrane-associated proteins, including dystrophin-associated complexes and components of costameres. Because of this essential structural function, Desmin antibody is frequently used in studies of muscle development, regeneration, and myofiber organization.
Mutations in the DES gene are associated with desmin-related myopathy, a group of hereditary myofibrillar myopathies characterized by progressive skeletal muscle weakness and cardiomyopathy. Abnormal Desmin aggregation and filament disorganization have also been observed in certain muscular dystrophies and cardiomyopathies. In diagnostic pathology, Desmin antibody is commonly applied to distinguish muscle-derived tumors such as rhabdomyosarcoma and leiomyosarcoma from non-myogenic neoplasms.
As a member of the intermediate filament protein family, Desmin contains a central alpha-helical rod domain flanked by head and tail domains that regulate filament assembly and protein-protein interactions. A Desmin antibody is suitable for investigating muscle cell differentiation, cytoskeletal architecture, cardiomyocyte integrity, and muscle-associated disease research applications.
The stated application concentrations are suggested starting points. Titration of the Desmin/Des antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human partial recombinant protein (AA 1-304) was used as the immunogen for this Desmin/Des antibody.
After reconstitution, the Desmin/Des antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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