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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Dectin-1, encoded by the CLEC7A gene, is a pattern recognition receptor involved in innate immune responses against fungal pathogens. Dectin-1 is expressed primarily in myeloid-derived immune cells including macrophages, dendritic cells, neutrophils, and inflammatory monocyte populations, where it functions as a receptor for fungal beta-glucans and related carbohydrate ligands. Activation of Dectin-1 signaling contributes to pathogen recognition, cytokine production, and initiation of antifungal immune responses.
Dectin 1 antibody, also referred to as CLEC7A antibody and beta-glucan receptor antibody in the literature, recognizes a membrane-associated lectin receptor that regulates innate immune signaling pathways linked to microbial sensing. Upon ligand binding, Dectin-1 activates intracellular signaling cascades involving SYK kinase and inflammatory transcriptional responses that coordinate myeloid cell activation and antimicrobial defense mechanisms. These functions make Dectin-1 an important marker for studying fungal immunity and innate inflammatory responses.
This Dectin 1 Antibody / Mouse Myeloid and Fungal Recognition Marker Antibody is uniquely positioned for studies involving mouse immune tissues and myeloid cell populations. Expression of Dectin-1 is associated with macrophage-rich and dendritic cell-rich environments involved in pathogen surveillance and inflammatory signaling. In tissue-based analyses, Dectin-1-positive immune cells may display membranous and cytoplasmic staining patterns consistent with receptor-mediated signaling activity.
In western blot applications, Dectin-1 is typically observed as a glycosylated receptor that may migrate over a range of molecular weights depending on post-translational modification state. Flow cytometry analysis supports characterization of Dectin-1-positive immune cell subsets following fixation and permeabilization or surface staining approaches. Mouse tissue expression patterns are consistent with the established role of Dectin-1 in innate immune defense and fungal pathogen recognition.
This rabbit polyclonal antibody is designed to detect Dectin-1 with consistent performance in research applications. A Dectin 1 antibody is suitable for detecting CLEC7A expression in studies of mouse myeloid biology, fungal recognition pathways, and innate immune receptor signaling.
For comprehensive detection of CLEC7A in innate immune and beta-glucan receptor studies, see our CLEC7A antibody.
Optimal dilution of the Dectin 1 Antibody / Mouse Myeloid and Fungal Recognition Marker Antibody should be determined by the researcher.
Recombinant mouse protein (amino acids Q17-L244) was used as the immunogen for the Dectin 1 antibody.
After reconstitution, the Dectin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Dectin-1 antibody, CLEC7A antibody, Beta-glucan receptor antibody, C-type lectin domain family 7 member A antibody, CLECSF12 antibody
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