- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Decorin Antibody / DCN (R31589)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R31589 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| UniProt | P07585 |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This Decorin antibody is available for research use only. |
|
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Decorin Antibody targets Decorin, encoded by the DCN gene. Decorin is a small leucine-rich proteoglycan that is a prominent component of the extracellular matrix, where it plays a critical role in regulating matrix organization, cell-matrix interactions, and tissue architecture. Decorin consists of a core protein decorated with a single dermatan sulfate or chondroitin sulfate glycosaminoglycan chain, allowing it to interact with structural matrix proteins as well as growth factors. Through these interactions, Decorin contributes to the mechanical integrity and signaling environment of connective tissues.
Functionally, Decorin binds directly to collagen fibrils, particularly type I collagen, and regulates fibrillogenesis by controlling collagen fiber diameter and spacing. This regulatory role is essential for maintaining normal tissue tensile strength and proper extracellular matrix assembly. In addition to its structural functions, Decorin acts as a signaling modulator by binding to and regulating the activity of multiple receptor tyrosine kinases and growth factors, including epidermal growth factor receptor and transforming growth factor beta. A Decorin Antibody is therefore useful for studying extracellular matrix biology, collagen organization, and growth factor signaling regulation.
Decorin expression is widespread in connective tissues such as skin, tendon, cartilage, bone, and vasculature, as well as in stromal compartments of many organs. It is predominantly localized to the extracellular matrix, where it associates with collagen fibers and other matrix components, although intracellular staining may be observed during synthesis and secretion. Fibroblasts are a major source of Decorin production, but endothelial cells and smooth muscle cells can also contribute to its expression depending on tissue context. These expression patterns make Decorin a valuable marker for stromal biology and matrix remodeling processes.
From a disease relevance perspective, alterations in Decorin expression or structure have been linked to a wide range of pathological conditions. Reduced or disorganized Decorin expression has been associated with fibrosis, impaired wound healing, and connective tissue disorders characterized by abnormal collagen architecture. In cancer biology, Decorin has been studied as a matrix-associated regulator of tumor growth and invasion, as changes in the stromal microenvironment can influence tumor progression and metastatic behavior. Decorin has also been examined in cardiovascular disease, where it contributes to vascular integrity and extracellular matrix stability.
At the molecular level, Decorin belongs to the small leucine-rich proteoglycan family, characterized by tandem leucine-rich repeats that mediate protein-protein interactions. These structural features enable Decorin to bind collagen fibers, growth factors, and cell surface receptors, integrating mechanical and biochemical signals within the extracellular matrix. Antibody-based detection of Decorin supports research into tissue development, extracellular matrix remodeling, fibrosis, and tumor-stroma interactions. NSJ Bioreagents provides reagents intended for research use to support investigations involving Decorin expression and extracellular matrix biology.
The stated application concentrations are suggested starting amounts. Titration of the Decorin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human partial recombinant protein (AA 31-359) was used as the immunogen for this Decorin antibody.
After reconstitution, the Decorin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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