- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Decorin Antibody Rabbit Monoclonal / DCN [clone DCN/8760R] (V4308)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4308-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4308-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4308SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | DCN/8760R |
| Purity | Protein A/G affinity |
| UniProt | P07585 |
| Localization | Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This Decorin antibody rabbit monoclonal is available for research use only. |
|
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Decorin Antibody Rabbit Monoclonal detects Decorin, a small leucine-rich extracellular matrix proteoglycan encoded by the DCN gene and widely expressed in connective tissues. Clone DCN/8760R is a rabbit monoclonal antibody developed for research applications focused on stromal biology, collagen organization, and extracellular matrix remodeling in normal and diseased tissues.
Decorin antibody, also referred to as DCN antibody and small leucine-rich proteoglycan decorin antibody in the literature, recognizes a secreted matrix proteoglycan composed of tandem leucine-rich repeat domains and a single glycosaminoglycan side chain. Decorin binds to fibrillar collagens, particularly type I collagen, where it regulates collagen fibrillogenesis, fiber diameter, and interfibrillar spacing. Through these structural interactions, Decorin contributes to tissue tensile strength and extracellular matrix stability.
In addition to its structural role, Decorin modulates signaling pathways by interacting with growth factors and receptor tyrosine kinases, including transforming growth factor beta and epidermal growth factor receptor. These interactions influence cellular proliferation, migration, and differentiation, positioning Decorin as both a matrix scaffold and a regulatory molecule within the tissue microenvironment. DCN expression is prominent in skin, tendon, ligament, cornea, prostate stroma, placenta, and other collagen-rich tissues. In tissue-based analyses, Decorin typically demonstrates extracellular stromal staining localized between collagen bundles and surrounding glandular structures.
Altered Decorin expression has been implicated in fibrosis, abnormal wound repair, and tumor progression, where extracellular matrix composition shapes stromal signaling and structural organization. Changes in Decorin distribution may accompany desmoplastic reactions and remodeling of collagen architecture in malignancy. A Decorin Antibody Rabbit Monoclonal such as clone DCN/8760R supports investigations into extracellular matrix biology, connective tissue development, fibrosis research, and stromal-tumor interactions. This antibody targets Decorin in research applications and is available from NSJ Bioreagents.
1. Optimal dilution of the Decorin antibody rabbit monoclonal should be determined by the researcher.
2. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.
A recombinant human Decorin protein fragment (within amino acids 212-336) was used as the immunogen for the Decorin antibody rabbit monoclonal.
Aliquot the Decorin antibody rabbit monoclonal and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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