DDR2 Antibody / Discoidin domain receptor 2 (RQ4561)

Description

DDR2 (Discoidin domain receptor 2) is a receptor tyrosine kinase that is activated by fibrillar collagens rather than soluble peptide growth factors. It contains an extracellular discoidin domain that mediates high-affinity binding to collagen, leading to receptor autophosphorylation and activation of downstream signaling pathways involved in cell adhesion, migration, proliferation, and extracellular matrix remodeling.

DDR2 is expressed in various mesenchymal-derived cells, including fibroblasts, chondrocytes, and smooth muscle cells. It plays key roles in connective tissue development, skeletal formation, and tissue repair processes. Altered DDR2 signaling has been linked to changes in extracellular matrix organization and cell-matrix communication, making it an important marker in studies of developmental biology and matrix regulation.

The DDR2 antibody is a valuable reagent for detecting endogenous DDR2 in applications such as western blot, immunohistochemistry, and immunofluorescence. Researchers use the DDR2 antibody from NSJ Bioreagents to monitor protein expression levels, analyze receptor localization, and investigate collagen-induced signaling. With high specificity and consistent performance, the DDR2 antibody supports detailed studies of receptor tyrosine kinase biology and collagen-mediated cellular responses.

Application Notes

Optimal dilution of the DDR2 antibody should be determined by the researcher.

Immunogen

Amino acids T801-E855 from the human protein were used as the immunogen for the DDR2 antibody.

Storage

After reconstitution, the DDR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.