- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
DDC Antibody / DOPA decarboxylase (FY12305)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12305 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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DDC antibody detects Aromatic-L-amino-acid decarboxylase, encoded by the DDC gene on chromosome 7p12.2. DDC antibody is widely used in neuroscience, metabolism, and clinical disorder research. DDC, also known as DOPA decarboxylase, catalyzes the decarboxylation of L-DOPA to dopamine and 5-hydroxytryptophan to serotonin, two critical neurotransmitters. By driving these biosynthetic steps, DDC plays a central role in catecholamine and serotonin metabolism, influencing behavior, cognition, and autonomic function.
Structurally, DDC is a ~53 kDa pyridoxal phosphate-dependent enzyme that functions as a homodimer. It contains a conserved active site lysine that forms a Schiff base with pyridoxal phosphate, essential for decarboxylation. The enzyme is localized to cytoplasm in neurons, endocrine cells, and peripheral tissues where neurotransmitter precursors are available.
Functionally, DDC is indispensable for synthesis of dopamine, norepinephrine, epinephrine, and serotonin. Its activity links amino acid metabolism with neurotransmission and hormone regulation. In the brain, DDC activity influences motor control, mood, and cognition. In peripheral tissues, it contributes to endocrine signaling and metabolic control. Researchers use DDC antibody to study neurotransmitter biosynthesis, psychiatric disease, and neurodegeneration.
Clinically, mutations in DDC cause aromatic L-amino acid decarboxylase deficiency, a rare metabolic disorder characterized by developmental delay, hypotonia, movement abnormalities, and autonomic dysfunction. DDC activity is also relevant in Parkinson's disease, where it influences dopamine availability and responsiveness to L-DOPA therapy. Dysregulated DDC expression has been linked to psychiatric disorders, endocrine diseases, and cancer. NSJ Bioreagents provides DDC antibody for neuroscience, metabolism, and clinical disorder research.
Experimentally, DDC antibody is applied in western blotting to detect the ~53 kDa enzyme, in immunohistochemistry to study expression in brain and endocrine tissues, and in immunofluorescence to localize cytoplasmic protein. Enzyme assays paired with DDC antibody confirm catalytic function in cell and tissue extracts.
Optimal dilution of the DDC antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence at the C-terminus of human DOPA decarboxylase/DDC was used as the immunogen for the DDC antibody.
After reconstitution, the DDC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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