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Home >> Antibodies >> DC-SIGN Antibody / CD209

DC-SIGN Antibody / CD209 [clone C209/1781] (V3452)

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  Catalog No Formulation Size Price (USD)  
Image V3452-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3452-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3452SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC testing of FFPE human lung carcinoma with DC-SIGN antibody (clone C209/1781). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20.
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IHC testing of FFPE human lung carcinoma with DC-SIGN antibody (clone C209/1781). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20.
IHC testing of FFPE human small intestine with DC-SIGN antibody (clone C209/1781). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20.
IHC testing of FFPE human colon carcinoma with DC-SIGN antibody (clone C209/1781). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20.
SDS-PAGE Analysis of Purified, BSA-Free DC-SIGN Antibody (clone C209/1781). Confirmation of Integrity and Purity of the Antibody.
Western blot testing of human liver and spleen lysate with DC-SIGN antibody. Predicted molecular weight ~46 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name C209/1781
Purity Protein G affinity chromatography
UniProt Q9NNX6
Localization Cytoplasmic, membranous, secreted
Applications Western blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT
Limitations This DC-SIGN antibody is available for research use only.
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Description

DC-SIGN / CD209 is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.

Application Notes

Titering of the DC-SIGN antibody may be required for optimal performance.

Immunogen

A human partial recombinant protein was used as the immunogen for the DC-SIGN antibody.

Storage

Store the DC-SIGN antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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