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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Drebrin (DBN1) is an actin-binding protein that plays a critical role in the regulation of dendritic spine morphology and synaptic plasticity in the nervous system. The DBN1 Antibody / Drebrin Synaptic Plasticity Marker Antibody is designed for studies focused on activity-dependent cytoskeletal remodeling and synaptic organization. DBN1 is encoded on chromosome 5q35 and belongs to a class of actin-binding proteins that regulate filament stability and spatial arrangement within neuronal processes, particularly in dendritic spines where synaptic signaling occurs.
The DBN1 antibody, also referred to as Drebrin antibody and Drebrin 1 antibody in the literature, recognizes a protein that is highly enriched in neurons and is developmentally regulated. Drebrin exists in embryonic (E) and adult (A) isoforms, with Drebrin A predominating in mature neurons and localizing to dendritic spines. In this context, DBN1 stabilizes actin filaments and contributes to spine structure, influencing synaptic strength and plasticity through modulation of cytoskeletal dynamics.
This DBN1 Antibody / Drebrin Synaptic Plasticity Marker Antibody is uniquely positioned for studies investigating synaptic remodeling and neuronal connectivity. Drebrin is closely associated with excitatory synapses and is involved in spine formation, maturation, and activity-dependent structural changes. Alterations in Drebrin distribution often reflect changes in synaptic function, making it a valuable marker for assessing neuronal plasticity in both physiological and experimental settings.
In addition to its structural role, Drebrin participates in signaling pathways that regulate actin dynamics and synaptic stability. It interacts with multiple cytoskeletal regulators and contributes to the coordination of signaling events that shape neuronal architecture. In immunohistochemistry and immunofluorescence applications, Drebrin is typically observed as cytoplasmic staining with enrichment in neuronal processes and dendritic regions, reflecting its association with actin-rich compartments. In western blot analysis, DBN1 is detected within a defined molecular weight range corresponding to its isoforms and post-translationally modified forms.
Dysregulation of Drebrin has been implicated in neurological disorders, including Alzheimerâs disease and other neurodegenerative conditions, where loss of dendritic spine integrity is a defining feature. Reduced Drebrin expression is associated with impaired synaptic function and cognitive decline, highlighting its importance as a marker of neuronal health and plasticity. As a result, DBN1 antibody detection is frequently used to study synaptic alterations and disease-related changes in neuronal structure.
The mouse monoclonal clone 4F6E7 provides consistent detection of DBN1, supporting research applications focused on synaptic plasticity, dendritic spine dynamics, and neuronal cytoskeletal organization. This DBN1 Antibody / Drebrin Synaptic Plasticity Marker Antibody is suitable for detecting DBN1 expression in studies of neuronal function and disease, offering a focused approach to evaluating activity-dependent changes in synaptic structure.
This antibody supports investigation of synaptic plasticity, dendritic spine remodeling, and disease-associated changes in DBN1 expression.
This antibody can be compared with our Drebrin Antibody / DBN1 Neuronal Actin-Binding Protein Antibody (clone DBN1/2880) for consistent detection of DBN1 across neuronal structure and cytoskeletal studies.
Optimal dilution of the DBN1 Antibody / Drebrin Synaptic Plasticity Marker Antibody should be determined by the researcher.
Recombinant human protein (amino acids H9-D649) was used as the immunogen for the DBN1 antibody.
After reconstitution, the DBN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Drebrin synaptic antibody, DBN1 spine marker antibody, Drebrin dendritic spine antibody, DBN1 neuronal plasticity antibody, Developmentally regulated brain protein antibody
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