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Home >> Antibodies >> D6 Antibody / ACKR2

D6 Antibody / ACKR2 (RQ4877)

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  Catalog No Formulation Size Price (USD)  
Image RQ4877 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) Raji, 2) HeLa, and 3) SW620 cell lysate with D6 antibody at 0.5ug/ml. Predicted molecular weight ~43 kDa, can be observed at 50-55 kDa.
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Western blot testing of human 1) Raji, 2) HeLa, and 3) SW620 cell lysate with D6 antibody at 0.5ug/ml. Predicted molecular weight ~43 kDa, can be observed at 50-55 kDa.
IHC staining of FFPE human placental tissue with D6 antibody at 1ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt O00590
Applications Western blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This D6 antibody is available for research use only.
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Description

The ACKR2 gene encodes a beta chemokine receptor, called Chemokine Receptor D6, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

Application Notes

Optimal dilution of the D6 antibody should be determined by the researcher.

Immunogen

Amino acids M138-A384 from the human protein were used as the immunogen for the D6 antibody.

Storage

After reconstitution, the D6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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