- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
D-dimer Antibody / Cross-linked fibrin fragment [clone FGG/13043R] (V5890)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5890-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5890-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5890SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | FGG/13043R |
| UniProt | P02679 |
| Localization | Secreted |
| Applications | Western Blot : 2-4ug/ml |
| Limitations | This D-dimer antibody is available for research use only. |
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D-dimer antibody targets a neoantigenic epitope present on the cross-linked fibrin fragment known as D-dimer, a specific fibrin degradation product generated during active coagulation and fibrinolysis. D-dimer is formed only after fibrinogen is converted to fibrin by thrombin, fibrin strands are covalently cross-linked by factor XIIIa, and the stabilized clot is subsequently cleaved by plasmin. This multistep requirement makes D-dimer a highly specific molecular marker of clot formation and breakdown rather than a marker of native fibrinogen or unprocessed fibrin.
D-dimer is derived primarily from the gamma chain region of fibrinogen (FGG) following cross-linking and proteolytic cleavage, creating a unique conformational epitope that is absent in intact fibrinogen, non-cross-linked fibrin, or individual fibrinogen chains. Antibodies directed against this neoepitope selectively recognize cross-linked fibrin degradation products, providing high specificity for biologically relevant clot turnover. As a result, D-dimer antibody reagents are fundamentally different from antibodies raised against fibrinogen alpha, beta, or gamma chains, which detect native circulating proteins rather than processed clot fragments.
The biological significance of D-dimer lies in its role as a direct indicator of ongoing or recent coagulation activity. Elevated D-dimer levels reflect activation of both the coagulation cascade and the fibrinolytic system, making D-dimer a widely used biomarker in thrombosis research and clinical diagnostics. D-dimer antibody tools are extensively applied in studies of venous thromboembolism, disseminated intravascular coagulation, cardiovascular disease, inflammation-associated coagulopathy, cancer-associated thrombosis, and sepsis-related clotting abnormalities.
In tissue-based and biochemical research, D-dimer antibody reagents are used to detect fibrin deposition and degradation within vascular and extravascular compartments. Localization of D-dimer-positive material provides insight into sites of active clot formation, fibrinolytic remodeling, and vascular injury. In cancer and inflammatory disease models, detection of cross-linked fibrin fragments can reveal interactions between coagulation pathways, immune cell infiltration, and tissue remodeling processes within the disease microenvironment.
The D-dimer antibody clone FGG/13043R is designed to recognize a neoantigenic determinant specific to the D-dimer fragment of cross-linked fibrin. Clone FGG/13043R does not detect native fibrinogen or uncleaved fibrin, supporting its use in research applications that require selective identification of fibrin degradation products. This monoclonal antibody enables precise investigation of coagulation dynamics, clot resolution, and fibrinolytic activity in physiological and pathological experimental systems.
1. Optimal dilution of the D-dimer antibody should be determined by the researcher.
2. This D-dimer antibody is recombinantly produced by expression in CHO cells.
Recombinant human FGA protein (exact sequence is proprietary) was used as the immuongen for the D-dimer antibody.
D-dimer antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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