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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Cytokeratin 7 Antibody / CK7 [clone KRT7/8121R] (V4285)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4285-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4285-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4285SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | KRT7/8121R |
| Purity | Protein A/G affinity |
| UniProt | P08729 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This Cytokeratin 7 antibody is available for research use only. |
|
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Cytokeratin 7 antibody targets Cytokeratin 7, also referred to as CK7, Keratin 7 or KRT7, a type II intermediate filament protein that forms part of the epithelial cytoskeleton. Cytokeratin 7 is predominantly localized in the cytoplasm of simple and glandular epithelial cells, where it contributes to structural integrity, cellular polarity, and resistance to mechanical stress. As a member of the keratin family, Keratin 7 pairs with type I keratins to assemble intermediate filaments that support epithelial architecture in both normal tissues and neoplastic conditions.
Keratin 7 expression is characteristically observed in epithelial linings of the lung, breast, biliary tract, pancreas, endometrium, ovary, and urinary tract, while it is typically absent in normal colorectal epithelium and stratified squamous epithelia. This distinct distribution pattern has made Cytokeratin 7 antibody a widely used reagent for distinguishing epithelial tumor origins, particularly in diagnostic pathology settings where CK7 positivity or negativity provides critical contextual information. Tumors derived from lung adenocarcinoma, breast carcinoma, ovarian carcinoma, cholangiocarcinoma, and urothelial carcinoma frequently demonstrate cytoplasmic Keratin 7 expression, whereas most colorectal adenocarcinomas remain CK7 negative.
Beyond its diagnostic utility, Cytokeratin 7 plays an active biological role in epithelial differentiation and cellular organization. Altered KRT7 expression has been associated with epithelial remodeling, glandular metaplasia, and malignant transformation, reflecting changes in cytoskeletal composition during disease progression. Keratin 7 expression patterns often correlate with epithelial lineage commitment and tumor phenotype, supporting its continued use as a marker of epithelial identity across research applications.
Due to its consistent cytoplasmic localization and lineage-specific expression, Cytokeratin 7 antibody is a valuable tool for detecting epithelial cells and epithelial-derived tumors in research studies. Antibodies recognizing Keratin 7 are commonly applied in histological and biochemical analyses to examine epithelial differentiation, tumor classification, and tissue architecture in both normal and diseased states.
Optimal dilution of the Cytokeratin 7 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the Cytokeratin 7 antibody.
Aliquot the Cytokeratin 7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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