- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Cytokeratin 10 Antibody SPM623 / Mouse Monoclonal [clone SPM623] (V3310)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3310-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V3310-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V3310SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | SPM623 |
| Purity | Protein G affinity chromatography |
| UniProt | P13645 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 0.1-0.2ug/ml for 30 min at RT |
| Limitations | This Cytokeratin 10 Antibody SPM623 is available for research use only. |
|
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Cytokeratin 10 Antibody SPM623 recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
Explore our Cytokeratin 10 Antibody KRT10/7804R, supported by Western blot and human skin immunohistochemistry data, for investigating epidermal differentiation and KRT10 expression.
Optimal dilution of the Cytokeratin 10 Antibody SPM623 should be determined by the researcher.
A cytoskeletal preparation extracted from human ectocervical epithelium was used as the immunogen for the Cytokeratin 10 Antibody SPM623.
Store the Cytokeratin 10 Antibody SPM623 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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