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Home >> Antibodies >> Cytochrome P450 3A4 Antibody / CYP3A4

Cytochrome P450 3A4 Antibody / CYP3A4 (RQ6860)

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  Catalog No Formulation Size Price (USD)  
Image RQ6860 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human HepG2 cells with Cytochrome P450 3A4 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Cytochrome P450 3A4 antibody.
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Flow cytometry testing of human HepG2 cells with Cytochrome P450 3A4 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Cytochrome P450 3A4 antibody.
Western blot testing of human HCCP cell lysate with Cytochrome P450 3A4 antibody. Expected molecular weight: 50-57 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P08684
Applications Western blot : 1-2ug/ml
Flow cytometry : 1-3ug/million cells
Limitations This Cytochrome P450 3A4 antibody is available for research use only.
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Description

Cytochrome P450 3A4 (abbreviated CYP3A4), is an important enzyme in the body, mainly found in the liver and in the intestine. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Application Notes

Optimal dilution of the Cytochrome P450 3A4 antibody should be determined by the researcher.

Immunogen

Amino acids NICVFPREVTNFLRKSVKR from the human protein were used as the immunogen for the Cytochrome P450 3A4 antibody.

Storage

After reconstitution, the Cytochrome P450 3A4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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