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Home >> Antibodies >> Cystatin C Antibody / Cystatin 3

Cystatin C Antibody / Cystatin 3 (RQ4449)

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  Catalog No Formulation Size Price (USD)  
Image RQ4449 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) COLO-320, 2) placenta, 3) HepG2 and 4) mouse brain lysate with Cystatin C antibody at 0.5ug/ml. Predicted molecular weight ~16 kDa.
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Western blot testing of human 1) COLO-320, 2) placenta, 3) HepG2 and 4) mouse brain lysate with Cystatin C antibody at 0.5ug/ml. Predicted molecular weight ~16 kDa.
IHC testing of FFPE mouse brain tissue with Cystatin C antibody at 2ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt P01034
Localization Secreted, cytoplasmic
Applications Western blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Direct ELISA : 0.1-0.5ug/ml (recombinant human protein)
Limitations This Cystatin C antibody is available for research use only.
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Description

Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family.

Application Notes

Optimal dilution of the Cystatin C antibody should be determined by the researcher.

Immunogen

Human Cystatin C recombinant protein (amino acids K31-A146) was used as the immunogen for the Cystatin C antibody.

Storage

After reconstitution, the Cystatin C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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