- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CYP2W1 Antibody / Cytochrome P450 2W1 (FY13252)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13252 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
CYP2W1 antibody detects Cytochrome P450 2W1, a monooxygenase enzyme involved in xenobiotic metabolism and drug activation. The UniProt recommended name is Cytochrome P450 2W1 (CYP2W1). This enzyme belongs to the cytochrome P450 superfamily, a large group of heme-thiolate proteins that catalyze oxidative reactions essential for detoxification and bioactivation of endogenous and exogenous compounds.
Functionally, CYP2W1 antibody identifies a 490-amino-acid membrane-bound enzyme localized to the endoplasmic reticulum. CYP2W1 utilizes NADPH–cytochrome P450 reductase as an electron donor to catalyze monooxygenation of various substrates including fatty acids, indole derivatives, and xenobiotics. Although minimally expressed in adult tissues, CYP2W1 is highly active in embryonic development and selectively re-expressed in certain cancers, where it contributes to prodrug metabolism and tumor-specific bioactivation.
The CYP2W1 gene is located on chromosome 7q22.3 and is expressed predominantly in colon, adrenal gland, and fetal tissues. Expression is regulated by epigenetic mechanisms such as DNA methylation and histone modification, restricting CYP2W1 activity to specific developmental and pathological contexts.
Pathologically, CYP2W1 has gained attention as a tumor-specific biomarker and therapeutic target due to its selective expression in colon, adrenal, and lung cancers. It catalyzes activation of several anticancer prodrugs, providing potential for targeted therapy. Conversely, its aberrant activity may contribute to tumor progression by metabolizing endogenous substrates into bioactive lipids. Research using CYP2W1 antibody supports studies in pharmacology, oncology, and drug metabolism.
CYP2W1 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect cytochrome P450 enzymes. NSJ Bioreagents provides CYP2W1 antibody reagents optimized for research in xenobiotic metabolism, cancer biology, and enzyme activation mechanisms.
Structurally, Cytochrome P450 2W1 contains a conserved P450 fold with heme-binding motifs (FGxGPR and Cys-pocket) and a hydrophobic N-terminal region for membrane anchoring. The active site accommodates small aromatic and aliphatic compounds, enabling broad substrate specificity. This antibody allows investigation of CYP2W1's function in tissue-specific metabolism and its emerging role in cancer therapeutics.
Optimal dilution of the CYP2W1 antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence at the N-terminus of human CYP2W1 was used as the immunogen for the CYP2W1 antibody.
After reconstitution, the CYP2W1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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