- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CYP1A2 Antibody [clone 499CT13.2.2] (F53655)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F53655-0.1ML | In ascites with 0.09% sodium azide | 0.1 ml | 399 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Ascites |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG3 |
| Clone Name | 499CT13.2.2 |
| Purity | Ascites |
| UniProt | P05177 |
| Localization | Cytoplasmic, membrane |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This CYP1A2 antibody is available for research use only. |
|
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
Titration of the CYP1A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 255-282 from the human protein was used as the immunogen for this CYP1A2 antibody.
Aliquot the CYP1A2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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