- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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CYP17A1 Antibody / P450c17 Antibody detects cytochrome P450 family 17 subfamily A member 1 (CYP17A1), a microsomal enzyme involved in steroid hormone biosynthesis. Commonly known as P450c17, CYP17A1 possesses both 17-alpha-hydroxylase and 17,20-lyase activities and helps regulate the production of glucocorticoid and sex steroid precursors. Its role at key branch points in steroidogenesis makes CYP17A1 an important target in endocrine, reproductive and cancer research.
P450c17 is a member of the cytochrome P450 enzyme family and is primarily associated with the endoplasmic reticulum of steroidogenic cells. Its 17-alpha-hydroxylase activity converts pregnenolone and progesterone into 17-alpha-hydroxylated steroids, while its 17,20-lyase activity contributes to the formation of androgen precursors such as dehydroepiandrosterone (DHEA). Regulation of these two catalytic activities helps determine the balance of steroid hormones produced in adrenal and gonadal tissues.
CYP17A1 is studied extensively in relation to adrenal function, gonadal steroidogenesis and androgen biosynthesis. Genetic alterations that impair CYP17A1 activity can cause 17-alpha-hydroxylase/17,20-lyase deficiency, a form of congenital adrenal hyperplasia characterized by abnormal steroid hormone production. P450c17 is also relevant to hormone-dependent cancer because CYP17A1-mediated androgen synthesis can contribute to androgen receptor signaling, making the enzyme particularly important in prostate cancer research.
This rabbit polyclonal CYP17A1 Antibody has been evaluated for detection of P450c17 by Western blot, immunohistochemistry and flow cytometry. Its application across complementary protein and cell-based methods supports research examining CYP17A1 expression and distribution without tying the product description to individual validation samples that may change over time.
NSJ Bioreagents supplies antibodies for research into steroid metabolism, endocrine signaling and cancer biology. A CYP17A1 Antibody can be used to investigate P450c17 expression in studies of steroidogenesis, androgen production, adrenal and gonadal biology, endocrine disorders and hormone-dependent cancer.
For additional research on CYP17A1 expression and steroid hormone biosynthesis, see our CYP17A1 Antibody / Steroid 17-Alpha-Hydroxylase Antibody page.
Optimal dilution of the CYP17A1 Antibody / P450c17 Antibody should be determined by the researcher.
Amino acids 383-419 (EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN-human) were used as the immunogen for the CYP17A1 antibody.
After reconstitution, the CYP17A1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
CYP17A1 antibody, P450c17 antibody, Cytochrome P450 17A1 antibody, CYP17 antibody, Cytochrome P450c17 antibody
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