- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Cyclophilin A Antibody (R33958)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R33958-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Dog, Pig, Cow |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 5478 |
| Localization | Cytoplasmic, secreted |
| Applications | Western Blot : 0.3-1ug/ml ELISA (peptide) LOD : 1:8000 |
| Limitations | This Cyclophilin A antibody is available for research use only. |
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Cyclophilin A Antibody recognizes Cyclophilin A (PPIA), a highly conserved peptidyl-prolyl cis-trans isomerase that functions as an essential molecular chaperone in eukaryotic cells. Cyclophilin A catalyzes the isomerization of peptide bonds preceding proline residues, a rate-limiting step in the folding of many proteins. Through this enzymatic activity, Cyclophilin A promotes proper protein conformation, supports protein stability, and contributes to the maintenance of cellular protein homeostasis. Because of its abundance and broad functional importance, Cyclophilin A is one of the most extensively studied members of the immunophilin protein family.
Cyclophilin A Antibody is widely used for investigating protein folding, intracellular signaling, and cellular stress responses. In addition to facilitating the maturation of newly synthesized proteins, Cyclophilin A participates in protein trafficking, assembly of multiprotein complexes, and regulation of numerous signaling pathways. Expression of Cyclophilin A is frequently elevated in cells experiencing oxidative stress, inflammatory stimulation, hypoxia, or other physiological challenges, highlighting its role in cellular adaptation and survival mechanisms.
Cyclophilin A Antibody is also valuable for studies of immune regulation and inflammation. Cyclophilin A was originally identified as the intracellular receptor for the immunosuppressive drug cyclosporin A and remains an important mediator of immune signaling pathways. Beyond its intracellular functions, Cyclophilin A can be secreted by activated cells and act as an extracellular signaling molecule that influences inflammatory responses, leukocyte migration, and tissue remodeling. These activities have made Cyclophilin A an important target in immunology and inflammatory disease research.
Cyclophilin A Antibody has significant relevance in cancer biology, cardiovascular disease, infectious disease, and metabolic research. Altered expression of Cyclophilin A has been reported in numerous pathological conditions where it may contribute to cell proliferation, migration, angiogenesis, and stress adaptation. Cyclophilin A has also been implicated in host-pathogen interactions and viral replication pathways, further expanding its importance in translational and therapeutic research. Consequently, Cyclophilin A continues to serve as both a valuable biomarker and a potential therapeutic target across multiple disease areas.
Cyclophilin A Antibody supports research involving molecular chaperones, protein folding, cellular stress responses, inflammation, signal transduction, oncology, cardiovascular biology, and infectious disease. As a central regulator of protein homeostasis and cellular adaptation, Cyclophilin A remains an important target for understanding both normal cellular physiology and disease-associated signaling mechanisms.
Researchers studying protein folding, molecular chaperones, cellular stress responses, and Cyclophilin A signaling pathways may also be interested in our Cyclophilin A Antibody / Protein Folding Chaperone Antibody.
Optimal dilution of the Cyclophilin A antibody should be determined by the researcher.
Amino acids ERFGSRNGKTSKK were used as the immunogen for this Cyclophilin A antibody.
Aliquot and store the Cyclophilin A antibody at -20oC.
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