- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Cyclin E1 Antibody Mouse Monoclonal / CCNE1 [clone CCNE1/2587] (V8192)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8192-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8192-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V8192SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG |
| Clone Name | CCNE1/2587 |
| Purity | Protein G affinity chromatography |
| UniProt | P24864 |
| Applications | ELISA (order BSA-free Format For Coating) : |
| Limitations | This Cyclin E1 antibody is available for research use only. |
|
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Cyclin E1 antibody recognizes Cyclin E1, a nuclear cell cycle regulator encoded by the CCNE1 gene. Also known as G1-S specific cyclin E1 and Cyclin E, this protein forms an active complex with cyclin-dependent kinase 2 to drive progression from the G1 phase into S phase of the cell cycle. Cyclin E1 antibody is widely used in research investigating cell proliferation, DNA replication control, and oncogenic cell cycle dysregulation.
Cyclin E1 accumulates during late G1 phase and reaches peak expression at the G1-S transition, where it promotes phosphorylation of substrates required for DNA synthesis initiation. The protein contains conserved cyclin box domains that mediate binding to CDK2 and regulate kinase activation. Cyclin E1 is predominantly localized to the nucleus, reflecting its role in coordinating replication origin firing and S phase entry. Tight transcriptional and proteasomal control of CCNE1 ensures orderly cell cycle progression and genomic stability.
Overexpression or amplification of CCNE1 has been reported in multiple malignancies, including ovarian, breast, lung, and gastric cancers. Elevated Cyclin E1 levels are frequently associated with increased proliferative activity and tumor progression. Immunostaining typically demonstrates strong nuclear localization in actively cycling cells. Clone CCNE1/2587 is a mouse monoclonal antibody developed to detect Cyclin E1 in research applications focused on cell cycle analysis, tumor biology, and proliferation assessment.
Optimal dilution of the Cyclin E1 antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 10-176) was used as the immunogen for this Cyclin E1 antibody.
Store the Cyclin E1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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