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Home >> Antibodies >> Cyclin D3 Antibody / CCND3

Cyclin D3 Antibody / CCND3 (F53065)

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  Catalog No Formulation Size Price (USD)  
Image F53065-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F53065-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of lysate from (1) human HeLa cell line, (2) mouse spleen, (3) rat lung, (4) rat stomach tissue using Cyclin D3 antibody at 1:1000. Predicted molecular weight ~33 kDa.
Western blot analysis of lysate from (1) human HeLa cell line, (2) mouse spleen, (3) rat lung, (4) rat stomach tissue using Cyclin D3 antibody at 1:1000. Predicted molecular weight ~33 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P48961
Applications Western blot : 1:500-1:1000
Limitations This Cyclin D3 antibody is available for research use only.
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    Pred. Reactivity : Bovine

Description

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Application Notes

Titration of the Cyclin D3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This Cyclin D3 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 33-66 amino acids from the N-terminal region of rat Ccnd3.

Storage

Aliquot the Cyclin D3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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