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Home >> Antibodies >> Cyclin D1 Antibody

Cyclin D1 Antibody (R32025)

  Catalog No Formulation Size Price (USD)  
Image R32025 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 389
Western blot testing of human 1) placenta, 2) HeLa and 3) 293 lysate with Cyclin D1 antibody. Predicted molecular weight: 32-36 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P24385
Applications Western blot : 0.1-0.5ug/ml
Limitations This Cyclin D1 antibody is available for research use only.
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Description

Cyclin D1, also known as CCND1, is a human gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al. (2003) found that prolactin induced IGF2 mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.

Application Notes

Optimal dilution of the Cyclin D1 antibody should be determined by the researcher.

Immunogen

Amino acids HDFIEHFLSKMPEAEENKQIIRKHAQT of human Cyclin D1 were used as the immunogen for the Cyclin D1 antibody.

Storage

After reconstitution, the Cyclin D1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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