- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
This antibody recognizes a protein of 36kDa, identified as Cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression. The antibody is useful in identifying mantle cell lymphomas (Cyclin D1 positive) from CLL/SLL and follicular lymphomas (Cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
The dilution stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the DCS-6 mAb to be titered up or down for optimal performance.
Human recombinant full length Cyclin D1 protein was used as the immunogen.
Store the Cyclin D1 antibody at 2-8°C. Conjugate is light sensitive, store in the dark.
Bcl-1, Bcl1
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.