- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD186 Antibody / CXCR6 Goat Polyclonal Antibody (R35867)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R35867-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Dog |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 10663 |
| Localization | Cytoplasmic, membranous |
| Applications | Western Blot : 0.3-1ug/ml IHC (FFPE) : 3.75ug/ml ELISA (peptide) LOD : 1:2000 |
| Limitations | This CD186 Antibody / CXCR6 Goat Polyclonal Antibody is available for research use only. |
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CD186 Antibody / CXCR6 Goat Polyclonal Antibody recognizes CXCR6, a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family. Also known as CD186, BONZO, and STRL33, CXCR6 functions as the receptor for CXCL16, a chemokine involved in immune cell recruitment and tissue localization. Unlike several other chemokine receptors that recognize multiple ligands, CXCR6 is principally associated with CXCL16, forming a signaling axis with important roles in immune surveillance and inflammatory responses.
CXCR6 is expressed by selected populations of T lymphocytes, natural killer T cells, and other immune cell subsets. Its expression is particularly associated with activated and memory T cells, including populations that establish long-term residence within peripheral tissues. Interaction with CXCL16 contributes to the positioning and retention of these cells in specialized tissue environments. The receptor therefore participates in immune responses that require coordinated communication between circulating lymphocytes and local cellular populations.
CXCL16 exists in both membrane-associated and soluble forms. Membrane-bound CXCL16 can facilitate interactions between CXCR6-expressing immune cells and neighboring cells, while proteolytic release generates a soluble chemokine capable of promoting directed cell migration. This dual functionality distinguishes the CXCL16-CXCR6 axis from many conventional chemokine signaling systems. CXCR6 activation can initiate intracellular signaling events associated with cellular movement, adhesion, and immune cell positioning.
The receptor has attracted considerable attention in studies of tissue-resident memory T cells, particularly within the liver, lungs, and other peripheral organs. CXCR6 contributes to the organization of local immune populations and can influence the persistence of lymphocytes within inflammatory microenvironments. Its expression has also been investigated in tumor-associated immune cells, where the CXCL16-CXCR6 axis may influence immune infiltration and interactions within the tumor microenvironment.
Historically, CXCR6 was identified as BONZO, a chemokine receptor capable of functioning as a coreceptor for certain immunodeficiency viruses under experimental conditions. This discovery contributed to early investigations of chemokine receptor biology and viral entry mechanisms. NSJ Bioreagents offers this CD186 Antibody for research examining CXCR6-mediated immune cell trafficking, tissue-resident lymphocyte populations, and chemokine-dependent cellular communication.
For additional antibodies targeting this chemokine receptor, see our CXCR6 Antibody FY12643.
Optimal dilution of the CD186 Antibody / CXCR6 Goat Polyclonal Antibody should be determined by the researcher.
Amino acids SEDNSKTFSASHN were used as the immunogen for this CXCR6 / CD186 antibody.
Aliquot and store the CXCR6 / CD186 antibody at -20oC.
CXCR6 antibody, C-X-C Chemokine Receptor Type 6 antibody, BONZO antibody, STRL33 antibody, CDw186 antibody
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