- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CXCR5 Antibody / CD185 / BLR1 / MDR15 [clone CXCR5/8146R] (V4213)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4213-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4213-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4213SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CXCR5/8146R |
| Purity | Protein A/G affinity |
| UniProt | P32302 |
| Localization | Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This CXCR5/CD185 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
CXCR5 antibody, also known as CD185 antibody, recognizes C-X-C motif chemokine receptor 5, a seven-transmembrane G protein-coupled receptor encoded by the CXCR5 gene and commonly referred to as Burkitt lymphoma receptor 1. CXCR5 is primarily localized to the plasma membrane of B lymphocytes and subsets of T cells, particularly follicular helper T cells, where it mediates chemokine-directed cell migration. As a member of the CXC chemokine receptor family, CXCR5 binds the ligand CXCL13 and plays a central role in organization of lymphoid follicles and germinal centers.
CXCR5 antibody detects a multi-pass transmembrane receptor composed of seven alpha-helical membrane-spanning domains, extracellular loops responsible for ligand binding, and intracellular domains that couple to heterotrimeric G proteins. Upon binding CXCL13, CXCR5 activates downstream signaling pathways that regulate cytoskeletal rearrangement, chemotaxis, and cell positioning within secondary lymphoid tissues. Through these mechanisms, CD185 directs B cells and follicular helper T cells to B cell follicles, supporting germinal center formation and adaptive immune responses.
Functionally, CXCR5 is critical for humoral immunity. Its expression defines follicular B cells and T follicular helper cells, which are essential for antibody affinity maturation and class switching. Dysregulated CXCR5 expression has been implicated in autoimmune diseases, chronic inflammatory conditions, and lymphoid malignancies. In certain B cell lymphomas, altered CXCR5 signaling may influence tumor cell localization and microenvironmental interactions. Because of its restricted expression pattern within lymphoid compartments, CXCR5 is widely used as a marker in immunology and hematopathology research.
The CXCR5 gene is located on chromosome 11 and is regulated during lymphocyte differentiation and activation. Detection of CXCR5 protein provides insight into lymphoid tissue architecture, B cell biology, and T follicular helper cell dynamics. As CD185, it is frequently used in flow cytometric and tissue-based analyses to characterize immune cell subsets and germinal center reactions.
This recombinant monoclonal CXCR5 antibody (clone CXCR5/8146R) targets CD185 protein in research applications. CXCR5 antibody supports investigation of lymphocyte trafficking, germinal center formation, immune regulation, and lymphoid malignancy-associated signaling pathways.
Optimal dilution of the CXCR5/CD185 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the CXCR5/CD185 antibody.
Aliquot the CXCR5/CD185 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
