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Home >> Antibodies >> CXCR4 Antibody

CXCR4 Antibody (F53179)

  Catalog No Formulation Size Price (USD)  
Image F53179-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F53179-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot testing of CXCR4 antibody at 1:2000 dilution and human samples: Lane 1: skeletal muscle; 2: spleen ; 3: uterus lysate; Predicted band size : 40 kDa
Western blot testing of CXCR4 antibody at 1:1000 dilution. Lane 1: Jurkat lysate; 2: rat heart lysate; Predicted band size : 40 kDa.
Availability 1-3 business days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P61073
Applications Western blot : 1:1000-2000
Limitations This CXCR4 antibody is available for research use only.
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Description

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Application Notes

Titration of the CXCR4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This CXCR4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 28-63 amino acids from the N-terminal region of human CXCR4.

Storage

Aliquot the CXCR4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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