- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CXCL13 Antibody / C-X-C motif chemokine 13 / BCA1 (FY12908)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12908 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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CXCL13 antibody detects C-X-C motif chemokine 13 (also known as B cell-attracting chemokine 1 or BCA1), a small secreted chemokine that directs B cell migration and lymphoid tissue organization. Encoded by the CXCL13 gene on chromosome 4q21.1, this protein belongs to the CXC chemokine family and binds to the receptor CXCR5 on B cells and follicular helper T cells, guiding them into lymphoid follicles during immune responses. CXCL13 plays a pivotal role in germinal center formation and antibody-mediated immunity.
Structurally, CXCL13 is a 109-amino-acid secreted protein of approximately 12 kilodaltons that adopts a characteristic chemokine fold stabilized by disulfide bonds. It is expressed by follicular dendritic cells, stromal cells, and certain epithelial and endothelial cells in lymphoid tissues. Upon secretion, CXCL13 establishes chemotactic gradients that attract CXCR5-positive lymphocytes to B cell zones within lymph nodes, spleen, and tertiary lymphoid structures.
The CXCL13 antibody is widely used in immunology, oncology, and infectious disease research to study chemokine signaling, germinal center formation, and immune cell trafficking. Western blot analysis detects a 12 kilodalton band corresponding to CXCL13, while immunohistochemistry reveals extracellular and stromal staining patterns within lymphoid tissues. This antibody supports quantitative and localization studies of B cell chemotactic signaling and lymphoid organogenesis.
Functionally, CXCL13 orchestrates the spatial organization of adaptive immune responses by regulating migration of B cells and T follicular helper cells. Overexpression of CXCL13 is observed in autoimmune diseases such as rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus, where ectopic lymphoid structures form in inflamed tissues. It also serves as a biomarker for certain cancers and viral infections, reflecting local immune activation. The CXCL13 antibody provides a sensitive and specific reagent for assessing chemokine expression in tissue sections and culture systems. NSJ Bioreagents validates this antibody for western blotting, immunohistochemistry, and ELISA, ensuring reliability for immune signaling and inflammation studies.
Optimal dilution of the CXCL13 antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence at the C-terminus of human CXCL13 was used as the immunogen for the CXCL13 antibody.
After reconstitution, the CXCL13 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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