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Home >> Antibodies >> CUEDC2 Antibody

CUEDC2 Antibody (R31066)

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  Catalog No Formulation Size Price (USD)  
Image R31066 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of CUEDC2 antibody and recombinant protein, 29KD with tag; Lane 1: 10ng; 2: 5ng; 3: 2.5ng; 4: 1.25ng
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Western blot testing of CUEDC2 antibody and recombinant protein, 29KD with tag; Lane 1: 10ng; 2: 5ng; 3: 2.5ng; 4: 1.25ng
IHC-P: CUEDC2 antibody testing of human thyroid cancer tissue
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q9H467
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This CUEDC2 antibody is available for research use only.
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Description

Cue Domain-Containing Protein 2 is involved in ubiquitin-and proteasome-mediated degradation of progesterone receptor (PR, or PGR) and estrogen receptor(ER)-alpha. Hartz(2011) mapped the CUEDC2 gene to chromosome 10q24.32 based on an alignment of the sequence with the genomic sequence (GRCh37). Using coimmunoprecipitation analysis and protein pull-down assays, Zhang et al.(2007) confirmed that CUEDC2 interacted with the PRB isoform of PR. Mutation analysis revealed that the IF domain of PRB and the CUE domain of CUEDC2 were required for the interaction. CUEDC2 reduced PRB protein content and promoted progesterone-induced PRB degradation via the ubiquitin-proteasome pathway.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the CUEDC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human Cue Domain-Containing Protein 2 (EAEEMKATYINLKPARKYRFH) was used as the immunogen for this CUEDC2 antibody (100% mouse homology).

Storage

After reconstitution, the CUEDC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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