- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CTNNBL1 Antibody / Catenin beta like 1 (FY12320)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12320 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
| Availability | 1-2 days |
| Species Reactivity | Human |
| Format | Lyophilized |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Immunogen affinity purified |
| Buffer | Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4. |
| UniProt | Q8WYA6 |
| Applications | Western Blot : 0.25-0.5ug/ml Flow Cytometry : 1-3ug/million cells ELISA : 0.1-0.5ug/ml |
| Limitations | This CTNNBL1 antibody is available for research use only. |
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CTNNBL1 antibody is used to study Catenin beta like 1, a nuclear protein that plays critical roles in RNA splicing, nuclear import, and regulation of the cell cycle. Unlike classical catenins that stabilize cadherin complexes at the cell membrane, Catenin beta like 1 is localized to the nucleus and interacts with core spliceosome proteins to ensure fidelity of pre-mRNA processing. This specialization makes CTNNBL1 a distinct member of the catenin-related family and a protein of increasing interest to molecular biologists.
Catenin beta like 1 contains armadillo (ARM) repeat domains that are structurally related to those in beta-catenin, but its function diverges toward nuclear events. Through these domains, CTNNBL1 associates with CDC5L, PRPF19, and additional splicing regulators, anchoring them within the spliceosomal complex. These interactions preserve accurate transcript maturation, prevent errors in gene expression, and safeguard the cell against the downstream consequences of mis-splicing. Because abnormal splicing can drive both oncogenesis and immune dysfunction, researchers frequently use CTNNBL1 antibody to map spliceosome activity and evaluate how this protein stabilizes nuclear machinery.
Recent studies have shown that Catenin beta like 1 is not limited to splicing but also functions in nuclear import pathways. CTNNBL1 assists in shuttling proteins that contain nuclear localization signals, ensuring that transcription factors and regulatory proteins reach the nucleus where they execute their functions. This process is fundamental for cell cycle regulation, DNA repair, and stress responses. When CTNNBL1 is disrupted, cells display impaired nuclear transport, altered gene expression, and reduced viability, underscoring its essential nature. With CTNNBL1 antibody, scientists can visualize these processes in detail using immunofluorescence, western blotting, and immunoprecipitation approaches.
Cancer biology has highlighted the importance of Catenin beta like 1. Abnormal expression of CTNNBL1 has been detected in colorectal cancer, breast cancer, and hematological malignancies, linking its function to tumor progression. Genetic polymorphisms in the CTNNBL1 gene have also been associated with autoimmune disease susceptibility and even with responses to viral infections. Researchers can therefore employ CTNNBL1 antibody to investigate how this nuclear factor contributes to disease risk, therapeutic response, and the molecular shifts that occur in malignancy. These insights are critical for understanding how dysregulated splicing and nuclear transport alter cell fate in pathological states.
The CTNNBL1 antibody offered by NSJ Bioreagents supports these lines of inquiry by providing reliable detection across a variety of assay platforms. In immunohistochemistry, it helps define nuclear localization patterns and expression levels in tissues, allowing correlation between CTNNBL1 levels and disease outcomes. In immunoprecipitation, it enables enrichment of spliceosomal complexes for downstream mass spectrometry or RNA analysis, clarifying which proteins and RNAs are bound by CTNNBL1 under different cellular states. In functional assays, use of CTNNBL1 antibody can help validate knockdown or overexpression experiments, ensuring that observed phenotypes directly reflect altered CTNNBL1 levels.
Beyond cancer and immunity, CTNNBL1 has relevance in developmental biology. Proper splicing and nuclear transport are fundamental for embryogenesis, and disruption of CTNNBL1 can impair tissue growth and differentiation. Neurobiology research has also turned attention to CTNNBL1, as RNA processing errors are linked to neurodegenerative conditions such as amyotrophic lateral sclerosis and spinal muscular atrophy. By applying CTNNBL1 antibody in these areas, investigators can track how RNA maturation and nuclear protein import influence neural survival and function.
As more laboratories study the consequences of RNA dysregulation, CTNNBL1 antibody has become an indispensable reagent for connecting nuclear mechanics to cellular phenotypes. Its applications in cancer, autoimmunity, virology, and neurodegeneration research reflect the broad significance of Catenin beta like 1 in human biology. The antibody provided by NSJ Bioreagents ensures dependable performance in both exploratory and translational studies, supporting researchers who are mapping the critical pathways that safeguard genomic stability and cellular health.
Optimal dilution of the CTNNBL1 antibody should be determined by the researcher.
E.coli-derived human CTNNBL1 recombinant protein (Position: Q122-E231) was used as the immunogen for the CTNNBL1 antibody.
After reconstitution, the CTNNBL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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