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Home >> Antibodies >> CSPG4 Antibody / NG2

CSPG4 Antibody / NG2 [clone LHM 2] (V7819)

  Catalog No Formulation Size Price (USD)  
Image V7819-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7819-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7819SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Immunofluorescence staining of fixed human HEPG2 cells with CSPG4 antibody (green, clone LHM 2) and Reddot nuclear stain (red).
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name LHM 2
Purity Protein G affinity chromatography
UniProt Q6UVK1
Applications Immunofluorescence : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This CSPG4 antibody is available for research use only.
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  • Applications : WB, Direct ELISA
    Reactivity : Human

Description

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. [UniProt]

Application Notes

Optimal dilution of the CSPG4 antibody should be determined by the researcher.

Immunogen

A 375P cells crude extract was used as the immunogen for this CSPG4 antibody

Storage

Store the CSPG4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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