- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CSDE1 Antibody / Cold shock domain-containing E1 (FY12960)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12960 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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CSDE1 antibody detects Cold shock domain-containing E1, an RNA-binding protein that regulates mRNA stability, translation, and stress response. The UniProt recommended name is Cold shock domain-containing protein E1 (CSDE1), also known as UNR (upstream of N-ras). This multifunctional RNA-binding factor modulates gene expression at post-transcriptional levels and participates in stress granule dynamics, cell differentiation, and viral replication control.
Functionally, CSDE1 antibody recognizes a 794-amino-acid protein containing five cold-shock domains (CSDs) that mediate single-stranded RNA binding. CSDE1 interacts with translation initiation factors and RNA helicases to regulate both cap-dependent and internal ribosome entry site (IRES)-mediated translation. It influences the expression of key regulatory proteins involved in cell growth, apoptosis, and stress adaptation. Through its control of mRNA turnover and translation, CSDE1 coordinates cellular response to nutrient deprivation, hypoxia, and oxidative stress.
The CSDE1 gene is located on chromosome 1p13.2 and is highly expressed in neurons, germ cells, and proliferating tissues. It associates with messenger ribonucleoprotein (mRNP) complexes and localizes to cytoplasmic granules under stress conditions. CSDE1 regulates the translation of c-Fos, Apaf1, and XIAP mRNAs, thereby balancing apoptosis and survival pathways. It also contributes to differentiation processes in embryonic stem cells and neuronal precursors through translational control mechanisms.
In virology, CSDE1 plays a dual role as a host factor that both supports and restricts viral replication, depending on the virus type. For example, it facilitates poliovirus IRES-mediated translation but limits the replication of certain RNA viruses by sequestering viral transcripts. In cancer, dysregulated CSDE1 expression promotes oncogenic translation programs, including MYC and PTEN pathway regulation. Its overexpression correlates with increased metastasis and poor prognosis in melanoma and prostate cancer.
CSDE1 antibody is used for immunoblotting, immunocytochemistry, and RNA immunoprecipitation to study RNA-protein interactions, translation control, and stress response mechanisms. In neuronal models, CSDE1 localization shifts dynamically between cytoplasm and stress granules, reflecting its regulatory versatility. Structural analyses reveal that each CSD contributes distinct RNA-binding affinities, allowing CSDE1 to recognize a broad spectrum of RNA targets and adapt to various signaling environments.
NSJ Bioreagents provides CSDE1 antibody reagents validated for applications in RNA biology, stress response, and translational regulation. These antibodies support research into mRNA metabolism, neuronal development, and cancer biology.
Optimal dilution of the CSDE1 antibody should be determined by the researcher.
E.coli-derived human CSDE1/NRU recombinant protein (Position: M1-Q775) was used as the immunogen for the CSDE1 antibody.
After reconstitution, the CSDE1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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