- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Crystallin Alpha B Antibody [clone CRYAB/7918] (V4184)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
V4184-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 519 | |
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V4184-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 229 | |
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V4184SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 519 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG |
| Clone Name | CRYAB/7918 |
| Purity | Protein A/G affinity |
| UniProt | P02511 |
| Localization | Cytoplasm, Nucleus |
| Applications | Western blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This Crystallin Alpha B antibody is available for research use only. |
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Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into Alpha, Beta and Gamma families, and the Beta- and Gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha-crystallins consist of three gene products, AlphaA-, AlphaB- and AlphaC-crystallin, which are members of the small heat shock protein family (HSP 20). Alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, Alpha-crystallins do not renature these proteins. Expression of AlphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human AlphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of AlphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
Optimal dilution of the Crystallin Alpha B antibody should be determined by the researcher.
Recombinant human full-length CRYAB protein was used as the immunogen for the Crystallin Alpha B antibody.
Aliquot the Crystallin Alpha B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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