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Liaw et al. (1996) [PubMed 8536644] stated that there are 2 G protein-coupled corticotropin-releasing hormone (CRH; MIM 122560) receptors, CRHR1 (MIM 122561) and CRHR2, which they termed the CRF2 receptor. CRH is a 41-amino acid peptide synthesized in the hypothalamus that is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge.
Titration of the CRFR2D antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This CRFR2D antibody was produced from rabbits immunized with a KLH conjugated synthetic peptide selected from the human CRFR2D.
Aliquot the CRFR2D antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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