Collagen I Antibody / COL1A1 (R32436)

Description

Collagen I is the most abundant collagen type in the human body and a major structural component of the extracellular matrix. It is composed of two alpha-1 chains and one alpha-2 chain, forming a triple-helical structure that provides tensile strength and structural integrity to connective tissues. Collagen I is found in skin, bone, tendon, ligament, and cornea, where it plays a key role in maintaining tissue architecture and mechanical resilience.

Collagen I synthesis and organization are critical for normal development, wound healing, and tissue repair. Alterations in its expression or structure have been linked to fibrotic diseases, connective tissue disorders, and certain tumor microenvironments. Because of its widespread presence and biological importance, Collagen I is a central focus in studies of tissue biology, biomaterials, and regenerative medicine.

The Collagen I antibody is an essential tool for detecting Collagen I in applications such as immunohistochemistry, western blot, and immunofluorescence. Researchers use the Collagen I antibody from NSJ Bioreagents to assess extracellular matrix composition, monitor tissue remodeling, and evaluate fibrosis-related changes. With high specificity and consistent performance, the Collagen I antibody supports research in cell biology, pathology, and extracellular matrix biology.

Application Notes

Optimal dilution of the Collagen I antibody should be determined by the researcher.

Immunogen

Amino acids YDFSFLPQPPQEKSQDGGRYYRA were used as the immunogen for the Collagen I antibody.

Storage

After reconstitution, the Collagen I antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.