- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
COL4A Antibody Recombinant Mouse MAb / Collagen IV [clone rCOL4/4742] (V8646)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8646-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8646-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8646SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rCOL4/4742 |
| Purity | Protein G affinity chromatography |
| UniProt | P02462 |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This COL4A antibody is available for research use only. |
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COL4A Antibody Recombinant Mouse MAb detects Collagen type IV, a major structural component of basement membranes and a critical element of the extracellular matrix. The clone rCOL4/4742 is a recombinant mouse monoclonal antibody developed for consistent research performance and supports evaluation of basement membrane organization in normal and diseased tissues.
COL4A antibody, also referred to as Collagen IV antibody and Type IV collagen antibody in the literature, recognizes network-forming collagen chains encoded by the COL4A gene family, including COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, and COL4A6. Unlike fibrillar collagens such as type I or type III collagen, Collagen IV assembles into a sheet-like scaffold that forms the structural backbone of basement membranes. These supramolecular networks interact with laminins, nidogens, and heparan sulfate proteoglycans to stabilize epithelial and endothelial layers while regulating cell adhesion, migration, differentiation, and filtration barrier function.
Collagen IV is widely distributed in vascular basement membranes, kidney glomeruli, lung alveolar septa, skeletal muscle endomysium, and epithelial basement membrane zones throughout the body. In renal tissue, Collagen IV outlines glomerular capillary loops and tubular basement membranes, while in other organs it highlights vascular and glandular basement membranes. This linear extracellular staining pattern makes a COL4A Antibody Recombinant Mouse MAb particularly useful for studying tissue architecture, angiogenesis, extracellular matrix remodeling, and tumor invasion where basement membrane integrity is disrupted.
Genetic alterations in COL4A family members are associated with hereditary nephropathies such as Alport syndrome, cerebrovascular small vessel disease, and ocular abnormalities. In oncology research, degradation or discontinuity of Collagen IV staining can indicate basement membrane breakdown and invasive potential. A COL4A Antibody Recombinant Mouse MAb such as clone rCOL4/4742 supports investigations into extracellular matrix biology, epithelial-mesenchymal transition, vascular pathology, and organ-specific basement membrane structure. This antibody targets Collagen IV in research applications and is available from NSJ Bioreagents.
Optimal dilution of the COL4A antibody recombinant mouse mAb should be determined by the researcher.
Purified human placental extract was used as the immunogen for the COL4A antibody recombinant mouse mAb.
Store the COL4A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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