• Tel: 858.663.9055
  • SeparatorEmail: info@nsjbio.com
  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Home >> Antibodies >> CLPS Antibody / Colipase

CLPS Antibody / Colipase [clone CLPS/12806R] (V5861)

NSJ bio Image Pdf Image
  Catalog No Formulation Size Price (USD)  
Image V5861-100UG 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide 100 ug 559
Image
V5861-20UG 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide 20 ug 259
Image
V5861SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Microvalidated Recrabbitmono
Bulk quote request
Western blot analysis of human pancreas, mouse pancreas, rat pancreas, hamster pancreas, guinea pig pancreas, and rabbit pancreas tissue lysates using CLPS/Colipase antibody (clone CLPS/12806R). A single immunoreactive band is observed at the predicted molecular weight (~12 kDa) for Colipase across all pancreatic samples except rabbit, with comparable signal intensity between species and minimal non-specific background.
›
Western blot analysis of human pancreas, mouse pancreas, rat pancreas, hamster pancreas, guinea pig pancreas, and rabbit pancreas tissue lysates using CLPS/Colipase antibody (clone CLPS/12806R). A single immunoreactive band is observed at the predicted molecular weight (~12 kDa) for Colipase across all pancreatic samples except rabbit, with comparable signal intensity between species and minimal non-specific background.
Western blot analysis of human pancreas, mouse pancreas, and rat pancreas tissue lysates using CLPS/Colipase antibody (clone CLPS/12806R). A distinct immunoreactive band is detected at the expected apparent molecular weight range for Colipase in all three pancreatic samples. Signal intensity is consistent across species, with minimal background staining observed in the blot. Predicted molecular weight ~12 kDa.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human pancreas using CLPS/Colipase antibody (clone CLPS/12806R). Predominantly cytoplasmic staining is observed in pancreatic acinar cells, with granular signal distributed throughout the cytoplasm, while surrounding stromal elements show minimal background. Inset shows PBS substituted for the primary antibody as a negative control. Heat-induced epitope retrieval was performed by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95oC, followed by cooling at RT for 20 minutes.
Western blot analysis of human pancreas tissue lysate using CLPS/Colipase antibody (clone CLPS/12806R). Predicted molecular weight ~12 kDa.
Western blot analysis of human pancreas tissue lysate using CLPS/Colipase antibody (clone CLPS/12806R). Predicted molecular weight ~12 kDa.
SDS-PAGE analysis of purified, BSA-free CLPS/Colipase antibody (clone CLPS/12806R) as confirmation of integrity and purity.
Species Reactivity Guinea Pig, Hamster, Human, Mouse, Rat
Format Purified
Host Rabbit
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name CLPS/12806R
UniProt P04118
Localization Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Western Blot : 2-4ug/ml
Limitations This CLPS/Colipase antibody is available for research use only.
Review this product on BioCompare and get a $20 Amazon gift card

Related Products

Description

CLPS antibody targets Colipase, a small secreted protein encoded by the CLPS gene that functions as an essential cofactor for pancreatic lipase during dietary fat digestion. Colipase binds pancreatic lipase and anchors it to lipid-water interfaces in the presence of bile salts, enabling efficient hydrolysis of triglycerides in the intestinal lumen. Colipase is synthesized primarily by pancreatic acinar cells and secreted into the duodenum, where it plays a critical role in lipid absorption and gastrointestinal physiology. CLPS antibody is therefore of interest in research focused on digestive enzyme regulation, pancreatic exocrine function, and nutrient metabolism.

Colipase is produced as a precursor protein that undergoes proteolytic processing to generate the active mature form. The protein belongs to the colipase family and contains conserved structural features required for lipase interaction and stabilization at the lipid interface. In addition to its classical role in digestion, CLPS expression has been examined in developmental and disease-related contexts involving pancreatic function, malabsorption syndromes, and exocrine pancreatic disorders. Clone CLPS/12806R is designed to recognize Colipase for research use in studies examining CLPS expression and secretion-associated biology.

Altered Colipase expression or activity has been associated with pancreatic insufficiency, lipid malabsorption, and gastrointestinal disease states. Changes in CLPS levels have also been explored in metabolic disorders and conditions affecting pancreatic enzyme secretion. Because proper colipase function is required for effective lipid digestion, CLPS remains an important research target in studies of digestive physiology, pancreatic health, and metabolic regulation. Clone CLPS/12806R provides a tool for examining Colipase expression and distribution in experimental systems relevant to pancreatic exocrine biology and lipid digestion pathways.

Application Notes

Optimal dilution of the CLPS/Colipase antibody should be determined by the researcher.

Immunogen

A recombinant fragment (around amino acids 1-112) of human CLPS protein (exact sequence is proprietary) was used as the immunogen for the CLPS/Colipase antibody.

Storage

CLPS/Colipase antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.

Related Products

   1.   View all CLPS/Colipase antibodies

Cross
Bulk Quote Request Form
Name*:
Organization*:
Email*:
Phone Number*:
Catalog No.*:
Comments and Specifics(amount, formulation, etc.)*:
Validation code: Captchapackage Image


Can't read the image? click here to refresh.
    *required field

Your bulk quote request has been submitted successfully!

Please contact us if you have any questions.