- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
DNGR-1 Antibody / Dendritic Cell Receptor Antibody [clone 1F6] (V8273)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8273-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V8273-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V8273SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Mouse |
| Format | Purified |
| Host | Rat |
| Clonality | Monoclonal (rat origin) |
| Isotype | Rat IgG1, kappa |
| Clone Name | 1F6 |
| Purity | Protein G affinity chromatography |
| UniProt | Q8RU4 |
| Applications | Flow Cytometry : 1-2ug/10^6 cells in 0.1ml Western Blot : 1-2ug/ml Immunofluorescence : 1-2ug/ml |
| Limitations | This DNGR-1 Antibody / Dendritic Cell Receptor Antibody is available for research use only. |
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C-Type Lectin Domain Family 9 Member A (CLEC9A) is a transmembrane C-type lectin receptor encoded by the CLEC9A gene and expressed predominantly by specialized dendritic cell populations. The DNGR-1 Antibody is useful for investigating dendritic cell biology, antigen presentation, and immune responses to cellular injury. DNGR-1 is localized to the plasma membrane and is best known for its expression on conventional type 1 dendritic cells (cDC1), a specialized subset of antigen-presenting cells that plays a central role in cross-presentation and activation of cytotoxic T-cell responses. These dendritic cells contribute to anti-viral immunity, anti-tumor immunity, and communication between innate and adaptive immune systems.
DNGR-1 antibody, also referred to as CLEC9A antibody, C-type lectin domain family 9 member A antibody, and dendritic cell NK lectin receptor antibody in the literature, recognizes a receptor that functions as a sensor of cellular damage. Clone 1F6 antibody has been utilized in published studies investigating CLEC9A-positive dendritic cell populations, antigen cross-presentation, and immune responses to tissue injury. DNGR-1 gained significant attention following the discovery that it recognizes filamentous actin exposed by necrotic and damaged cells, allowing dendritic cells to identify sites of tissue damage and efficiently acquire associated antigens.
A defining feature of DNGR-1 biology is its role in antigen cross-presentation. Following recognition of dead-cell material, DNGR-1 promotes routing of antigens into pathways that facilitate presentation on MHC class I molecules and activation of CD8-positive T lymphocytes. This specialized process allows the immune system to generate cytotoxic responses against infected or malignant cells. Because cDC1 dendritic cells are particularly efficient at cross-presentation, DNGR-1 has become one of the most widely used markers for identifying dendritic cell populations associated with cellular immunity and tumor surveillance.
DNGR-1 has also emerged as an important target in vaccine development and immunotherapy research. Numerous studies have explored strategies that direct antigens to CLEC9A-positive dendritic cells to enhance immune activation and improve antigen-specific T-cell responses. The ability to selectively target highly specialized antigen-presenting cells has generated considerable interest in cancer immunotherapy, infectious disease research, and next-generation vaccine design. Published studies utilizing clone 1F6 antibody have contributed to the characterization of CLEC9A-positive dendritic cells and their role in adaptive immune activation.
Beyond its role in antigen presentation, DNGR-1 contributes to coordination of immune responses following tissue damage and cellular stress. By linking recognition of dead-cell material with adaptive immune activation, the receptor helps ensure that important antigens are efficiently processed and presented to the immune system. A DNGR-1 antibody can support studies of dendritic cell biology, antigen cross-presentation, dead-cell sensing, tumor immunity, vaccine targeting, and innate-adaptive immune communication. General antibody-based approaches may be used to evaluate DNGR-1 expression in a variety of research applications. NSJ Bioreagents offers clone 1F6 antibody to support investigations of dendritic cell receptor biology and immune regulation.
Researchers studying antigen cross-presentation, cDC1 biology, and dendritic cell-mediated immune activation may also be interested in our Dendritic Cell Antibody landing page featuring markers involved in dendritic cell identification, antigen uptake, and T-cell priming.
Optimal dilution of the DNGR-1 Antibody / Dendritic Cell Receptor Antibody should be determined by the researcher.
RBL-2H3 cells expressing mouse CLEC9A fused to an HA epitope.
Store the CLEC9A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CLEC9A antibody, C-type lectin domain family 9 member A antibody, DNGR1 antibody, Dendritic cell NK lectin receptor antibody, C-type lectin receptor antibody
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