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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Claudin18.2 (CLDN18.2) is a tight junction-associated transmembrane protein involved in epithelial barrier formation, cell-cell adhesion, and gastrointestinal epithelial differentiation. Claudin18.2 Antibody / Gastrointestinal Cancer Marker is suitable for investigations involving gastric cancer biology, pancreatic tumor signaling, epithelial junction proteins, and therapeutic target-associated oncology pathways. Claudin18.2 represents a stomach-restricted splice variant of the Claudin18 gene that becomes aberrantly exposed or overexpressed in several gastrointestinal malignancies, making it an important biomarker and emerging therapeutic target in cancer research.
Claudin18.2 antibody, also referred to as CLDN18.2 antibody, Claudin 18 isoform 2 antibody, Tight junction protein Claudin18.2 antibody, and Claudin18 gastric cancer marker antibody in the literature, recognizes a membrane-associated junctional protein belonging to the claudin family of tight junction regulators. Claudins are critical structural components of epithelial tight junctions that regulate paracellular permeability and epithelial polarity. Claudin18.2 is normally enriched within differentiated gastric mucosal epithelial cells, where it contributes to maintenance of epithelial barrier integrity and tissue compartmentalization.
In malignant tissues, disruption of epithelial polarity and junctional organization can expose Claudin18.2 epitopes that are otherwise restricted within tightly organized junctional complexes. This altered accessibility has made Claudin18.2 a major focus in gastrointestinal oncology and targeted therapeutic development. Increased Claudin18.2 expression has been reported in gastric adenocarcinoma, gastroesophageal carcinoma, pancreatic adenocarcinoma, and additional epithelial-derived malignancies. Because of its relatively restricted normal tissue distribution combined with tumor-associated exposure, Claudin18.2 has emerged as a clinically important biomarker in precision oncology research.
Claudin18.2-targeted therapeutic strategies, including monoclonal antibody-based approaches, are under active investigation for treatment of gastrointestinal cancers. Interest in Claudin18.2 biology has expanded substantially with development of therapeutic antibodies such as zolbetuximab directed against extracellular domains of the protein. As a result, Claudin18.2 is increasingly studied in translational oncology, tumor stratification, and epithelial differentiation-associated cancer signaling pathways.
Immunohistochemistry and western blot analyses support detection of Claudin18.2/CLDN18.2 expression in epithelial-associated samples, consistent with the expected localization of this tight junction transmembrane protein in gastrointestinal tissues and tumor-associated epithelial populations. The available validation data support use of clone CLDN18.2/8559R for investigations involving epithelial differentiation, gastrointestinal cancer biology, membrane-associated junctional proteins, and therapeutic target-associated oncology research.
An antibody targeting Claudin18.2 can therefore support studies involving gastrointestinal tumor biomarkers, epithelial tight junction proteins, gastric and pancreatic cancer signaling, therapeutic target validation, and epithelial differentiation-associated membrane protein biology.
Claudin18.2 is a tight junction-associated epithelial marker widely studied in gastric and pancreatic cancer biology; explore related tumor-associated targets on our Cancer Antibodies landing page.
Optimal dilution of the Claudin18.2 Antibody / Gastrointestinal Cancer Marker should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-100) from the human protein was used as the immunogen for the Claudin18.2 antibody.
Store the Claudin18.2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Claudin18.2 antibody, CLDN18.2 antibody, Claudin 18 isoform A2 antibody, Tight junction protein Claudin18.2 antibody, Gastrointestinal cancer marker antibody, Gastric cancer marker antibody
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