- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CKM Antibody / Creatine kinase M-type [clone CKMM/13033R] (V5858)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5858-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5858-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
|
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V5858SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CKMM/13033R |
| UniProt | P06732 |
| Localization | Cytoplasm |
| Applications | ELISA : |
| Limitations | This CKM/Creatine kinase M-type antibody is available for research use only. |
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CKM antibody targets Creatine kinase M-type, a cytosolic enzyme encoded by the CKM gene that catalyzes the reversible transfer of a phosphate group between ATP and creatine, generating phosphocreatine and ADP. Creatine kinase M-type is a key component of the phosphagen system that buffers intracellular ATP levels in cells with high and rapidly changing energy demands. This isoform represents the muscle-type creatine kinase and is highly expressed in skeletal muscle fibers and cardiomyocytes, where efficient energy transfer is essential for contraction and cellular homeostasis. CKM antibody is therefore commonly used in research focused on muscle metabolism, bioenergetics, and creatine kinase system regulation.
Creatine kinase M-type functions primarily as a homodimer but can also form heterodimers with the brain-type creatine kinase subunit, resulting in the CK-MB isoenzyme. The protein belongs to the creatine kinase family and contains conserved catalytic domains required for creatine binding and phosphotransfer activity. In addition to mature muscle tissue, CKM expression has been reported during myogenic differentiation and muscle regeneration, supporting its role in muscle development and repair. Clone CKMM/13033R is designed to recognize Creatine kinase M-type for research use in studies examining muscle-associated energy metabolism and creatine kinase dynamics.
Alterations in Creatine kinase M-type expression or activity have been investigated in a variety of pathological contexts, including muscular dystrophies, myopathies, cardiac injury, and metabolic stress conditions. Changes in CKM levels are commonly associated with muscle damage and impaired energy handling, reflecting disruption of phosphocreatine-dependent ATP buffering. Because the creatine kinase system is central to muscle performance, fatigue resistance, and recovery, CKM remains an important research target in studies of muscle physiology, disease mechanisms, and metabolic adaptation. Clone CKMM/13033R provides a tool for examining Creatine kinase M-type expression and distribution in experimental systems relevant to skeletal and cardiac muscle biology.
1. Optimal dilution of the CKM/Creatine kinase M-type antibody should be determined by the researcher.
2. This CKM/Creatine kinase M-type antibody is recombinantly produced by expression in human HEK293 cells.
Recombinant human CKM protein was used as the immunogen for the CKM/Creatine kinase M-type antibody.
CKM/Creatine kinase M-type antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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