- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CIP2A Antibody / p90 Autoantigen (C-Terminal Region) (R32285)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R32285 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| UniProt | Q8TCG1 |
| Applications | Western blot : 0.1-0.5ug/ml |
| Limitations | This CIP2A antibody is available for research use only. |
|
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Protein CIP2A, also known as 'cancerous inhibitor of PP2A' and p90, is a protein that in humans is encoded by the KIAA1524 gene. It is required for the malignant cellular growth and for in vivo tumor formation. In accordance with the oncogenic role of CIP2A, overexpression promotes Ras-elicited cell growth and transforms immortalized human cells (HEK-TERVs). More recently CIP2A has been shown to regulate phosphorylation and activity of many other oncoproteins and to drive malignant cell growth and tumorigenesis in various human cancer types. Importantly, CIP2A deficient mice are viable, suggesting that targeting of oncogenic function of CIP2A would not result in serious side-effects.
Optimal dilution of the CIP2A antibody should be determined by the researcher.
Amino acids EVQKAQLEGRLEEKESLVKLQQEELNKHSHMIAMIH of human KIAA1524 were used as the immunogen for the CIP2A antibody.
After reconstitution, the CIP2A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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