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Home >> Antibodies >> CIITA Antibody

CIITA Antibody (RQ6846)

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  Catalog No Formulation Size Price (USD)  
Image RQ6846 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human Raji cells with CIITA antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= CIITA antibody.
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Flow cytometry testing of human Raji cells with CIITA antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= CIITA antibody.
Western blot testing of 1) human K562, 2) human HepG2, 3) rat spleen, 4) rat PC-12 and 5) mouse spleen tissue lysate with CIITA antibody. Predicted molecular weight ~123 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P33076
Applications Western blot : 1-2ug/ml
Flow cytometry : 1-3ug/million cells
Direct ELISA : 0.1-0.5ug/ml
Limitations This CIITA antibody is available for research use only.
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  • Applications : WB, IHC-P
    Reactivity : Human, Mouse, Rat

Description

CIITA is a human gene which is mapped to 16p13. This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the master control factor for the expression of these genes. Also, the protein binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.

Application Notes

Optimal dilution of the CIITA antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids Y34-A1038) was used as the immunogen for the CIITA antibody.

Storage

After reconstitution, the CIITA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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