- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Chromogranin A Antibody Mouse Monoclonal [clone CHGA/4223] (V9385)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9385-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9385-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9385SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | CHGA/4223 |
| Purity | Protein A/G affinity |
| UniProt | P10645 |
| Localization | Finely granular cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Chromogranin A Antibody Mouse Monoclonal is available for research use only. |
|
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Chromogranin A antibody recognizes Chromogranin A, a secretory granule protein encoded by the CHGA gene and widely used as a marker of neuroendocrine differentiation. Chromogranin A Antibody Mouse Monoclonal (clone CHGA/4223) is developed to detect this cytoplasmic granule-associated protein in research applications involving endocrine and neuroendocrine tissues. Chromogranin A localizes predominantly to the cytoplasm within dense-core secretory vesicles, where it plays an important role in hormone storage, granule formation, and regulated secretion.
Chromogranin A antibody, also referred to as CHGA antibody and CgA antibody in the literature, targets a member of the granin family of acidic secretory proteins. After synthesis, Chromogranin A undergoes proteolytic processing to generate several biologically active peptides, including vasostatin, pancreastatin, and catestatin, which contribute to modulation of cardiovascular tone, metabolic regulation, and neuroendocrine signaling pathways. Within the trans-Golgi network and secretory granules, Chromogranin A promotes aggregation of peptide hormones and stabilizes the dense-core structure characteristic of neuroendocrine cells.
CHGA expression is characteristic of adrenal medulla chromaffin cells, pancreatic islet cells, gastrointestinal enteroendocrine cells, parathyroid tissue, and dispersed neuroendocrine cells throughout multiple organ systems. The expected immunostaining pattern is cytoplasmic granular positivity reflecting localization to secretory vesicles. Because of this restricted distribution, Chromogranin A serves as a robust marker for identifying neuroendocrine lineage in research studies.
In tumor biology investigations, Chromogranin A expression is frequently evaluated in neuroendocrine neoplasms including carcinoid tumors, pancreatic neuroendocrine tumors, small cell carcinoma, medullary thyroid carcinoma, and pheochromocytoma. Strong cytoplasmic staining supports neuroendocrine differentiation, while most non-neuroendocrine carcinomas demonstrate limited or absent expression. Chromogranin A Antibody Mouse Monoclonal (clone CHGA/4223) enables consistent detection of Chromogranin A expression patterns in normal and neoplastic tissues for research use at NSJ Bioreagents.
This CHGA antibody is part of a broader Chromogranin A antibody panel offered by NSJ Bioreagents.
Optimal dilution of the Chromogranin A Antibody Mouse Monoclonal should be determined by the researcher.
A portion of amino acids 23-165 was used as the immunogen for the Chromogranin A antibody mouse monoclonal.
Aliquot the Chromogranin A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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