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Home >> Antibodies >> Chromogranin A Antibody

Chromogranin A Antibody [clone CHGA/777] (V2457CF488)

  Catalog No Formulation Size Price (USD)  
Image V2457CF488-100T 500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 Tests 519
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Availability 1-3 business days
Species Reactivity Human
Format CF488 Conjugate
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CHGA/777
Purity Protein G affinity chromatography
UniProt P10645
Localization Cytoplasmic
Applications Flow cytometry : 5ul per test per one 10^6 cells in 0.1ml or 5ul per 100ul of whole blood
Limitations This Chromogranin A antibody is available for research use only.
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Description

Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Application Notes

Optimal dilution of the Chromogranin A antibody should be determined by the researcher.

Immunogen

Recombinant full-length human protein was used as the immunogen for the Chromogranin A antibody.

Storage

Store the Chromogranin A antibody at 2-8oC, protected from light.

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