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Home >> Antibodies >> Chromogranin A Antibody

Chromogranin A Antibody [clone CHGA/4223] (V9385)

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  Catalog No Formulation Size Price (USD)  
Image V9385-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9385-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9385SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free Chromogranin A antibody (clone CHGA/4223) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free Chromogranin A antibody (clone CHGA/4223) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CHGA/4223
Purity Protein A/G affinity
UniProt P10645
Localization Finely granular cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Chromogranin A antibody is available for research use only.
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Description

Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Application Notes

Optimal dilution of the Chromogranin A antibody should be determined by the researcher.

Immunogen

A portion of amino acids 23-165 was used as the immunogen for the Chromogranin A antibody.

Storage

Aliquot the Chromogranin A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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