- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Calgranulin C Antibody / S100A12 Antibody [clone S100A12/8952R] (V4741)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4741-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4741-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4741SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | S100A12/8952R |
| Purity | Protein A/G affinity |
| UniProt | P80511 |
| Localization | Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Calgranulin C Antibody is available for research use only. |
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S100 calcium binding protein A12 (S100A12) is a member of the S100 family of calcium-binding proteins encoded by the S100A12 gene and expressed predominantly by neutrophils and activated myeloid cells. Calgranulin C Antibody enables detection of S100A12 protein in cells and tissues and supports studies investigating inflammatory cell biology and innate immune responses. S100A12, also widely known as Calgranulin C and EN-RAGE (extracellular newly identified RAGE-binding protein), functions as a pro-inflammatory mediator involved in leukocyte activation, cytokine signaling, and host defense mechanisms.
S100A12 belongs to the EF-hand calcium-binding protein family and participates in inflammatory signaling through interactions with receptors such as the receptor for advanced glycation end products (RAGE). Binding of S100A12 to RAGE can activate downstream signaling pathways associated with inflammation, leukocyte recruitment, and endothelial activation. Because of these biological roles, S100A12 has been extensively studied in inflammatory disorders including autoimmune diseases, cardiovascular inflammation, and chronic inflammatory conditions where neutrophil activation plays a central role.
Expression of S100A12 is highly enriched in neutrophils and granulocytes and is commonly associated with inflammatory cell infiltration in tissues. In histological samples, S100A12 protein is typically detected within the cytoplasm of neutrophils and other myeloid-derived inflammatory cells. These staining patterns allow researchers to identify infiltrating inflammatory cells and evaluate immune responses within tissue microenvironments. Detection of S100A12 is therefore useful in studies examining inflammatory cell distribution and the contribution of neutrophil-driven inflammation to disease processes.
A recombinant rabbit monoclonal antibody, clone S100A12/8952R, recognizes S100A12 protein and supports detection of Calgranulin C expression in research applications. Calgranulin C Antibody allows investigators to evaluate S100A12 distribution in tissues, characterize inflammatory cell populations, and study the biological role of S100A12 in innate immune signaling pathways. Such studies contribute to a broader understanding of inflammatory regulation, leukocyte biology, and the involvement of S100A12 in inflammatory disease mechanisms.
Optimal dilution of the Calgranulin C Antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-95) from the human protein was used as the immunogen for the Calgranulin C Antibody.
Aliquot the Calgranulin C Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
S100A12 antibody, EN-RAGE antibody, S100 calcium binding protein A12 antibody, Calgranulin C protein antibody
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