- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CGB3 Antibody / Choriogonadotropin subunit beta 3 [clone HCGb/7512R] (V5855)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5855-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5855-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5855SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | HCGb/7512R |
| Purity | Protein A affinity |
| UniProt | P01233 |
| Localization | Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CGB3/Choriogonadotropin subunit beta 3 antibody is available for research use only. |
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CGB3 Antibody targets Choriogonadotropin subunit beta 3, a glycoprotein hormone subunit that forms part of human chorionic gonadotropin (hCG), a key regulator of early pregnancy and trophoblast biology. Choriogonadotropin subunit beta 3 is encoded by the CGB3 gene, one of several closely related beta subunit genes clustered on chromosome 19 that contribute to hCG production. The beta subunit confers biological specificity to the hormone and distinguishes hCG from other glycoprotein hormones such as luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone, which share a common alpha subunit.
Choriogonadotropin subunit beta 3 is primarily synthesized and secreted by placental syncytiotrophoblasts, where it plays an essential role in maintaining the corpus luteum, supporting progesterone production, and promoting uterine receptivity during early gestation. In addition to its endocrine role, hCG beta subunits have been implicated in trophoblast differentiation, angiogenesis, and immune modulation at the maternal-fetal interface. Expression of CGB3 is tightly regulated during normal pregnancy, with highest levels observed during the first trimester, followed by a gradual decline as placental endocrine function matures.
Beyond normal placental physiology, aberrant expression of Choriogonadotropin subunit beta 3 has been documented in a variety of pathological contexts. Elevated or ectopic expression of hCG beta subunits, including CGB3, has been reported in gestational trophoblastic disease and several non-trophoblastic malignancies, where expression may reflect dedifferentiation or hormone-driven signaling pathways. In these settings, CGB3 antibody reagents are widely used to examine hormone production, tumor-associated antigen expression, and diagnostic marker distribution in tissue sections and cell-based models.
At the cellular level, Choriogonadotropin subunit beta 3 is synthesized in the endoplasmic reticulum, undergoes glycosylation within the Golgi apparatus, and is secreted into the extracellular space as part of the intact hCG heterodimer. The protein belongs to the glycoprotein hormone beta subunit family and contains conserved cysteine residues that form disulfide bonds critical for proper folding and receptor interaction. Due to extensive glycosylation, hCG beta subunits often display higher apparent molecular weights than predicted by primary amino acid sequence alone when analyzed by SDS-PAGE.
CGB3 Antibody is a valuable tool for studying placental development, reproductive endocrinology, and hormone-associated tumor biology. Detection of Choriogonadotropin subunit beta 3 expression supports investigations into trophoblast function, endocrine signaling, and disease-associated dysregulation of hCG-related pathways.
Choriogonadotropin subunit beta 3 is a glycoprotein hormone subunit encoded by the CGB3 gene and belongs to the chorionic gonadotropin beta family, which plays an essential role in placental development and endocrine signaling during pregnancy. Expression of CGB3 contributes to the biological activity of human chorionic gonadotropin and is tightly regulated in trophoblastic tissues and other hormone-associated biological systems. Clone HCGb/7512R is designed to recognize Choriogonadotropin subunit beta 3 for research use in molecular and cellular studies.
CGB3 Antibody is intended for research applications involving analysis of Choriogonadotropin subunit beta 3 expression in placental biology and hormone-associated systems. In addition to physiological expression, dysregulated expression of beta subunits of chorionic gonadotropin, including CGB3, has been reported in a range of hormone-related pathological contexts, supporting continued investigation of this protein in both normal and disease-associated settings. Clone HCGb/7512R provides a tool for researchers examining CGB3 expression and distribution in relevant experimental models.
1. Optimal dilution of the CGB3/Choriogonadotropin subunit beta 3 antibody should be determined by the researcher.
2. This CGB3/Choriogonadotropin subunit beta 3 antibody is recombinantly produced by expression in human HEK293 cells.
Recombinant full-length human CGB protein was used as the immunogen for the CGB3/Choriogonadotropin subunit beta 3 antibody.
CGB3/Choriogonadotropin subunit beta 3 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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